AI Article Synopsis
- COVID-19 is caused by the SARS-CoV-2 virus and has been labeled a pandemic, affecting many individuals globally.
- Four cases of COVID-19 were reported where patients tested positive for viral RNA for about 61 days despite receiving various treatments.
- The antiviral treatment using ritonavir-boosted danoprevir successfully led to two to three consecutive negative test results for SARS-CoV-2 RNA, indicating its potential effectiveness for persistent cases.
Article Abstract
Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375796 | PMC |
| http://dx.doi.org/10.1590/0037-8682-0372-2020 | DOI Listing |
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