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A real-world comparison among third-generation antiseizure medications: Results from the COMPARE study.
Epilepsia
February 2024
Science of Health Department, School of Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Objective: There are few comparative data on the third-generation antiseizure medications (ASMs). We aimed to assess and compare the effectiveness of brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) in people with epilepsy (PWE). Efficacy and tolerability were compared as secondary objectives.
View Article and Find Full Text PDFStatus epilepticus in pregnancy: a literature review and a protocol proposal.
Expert Rev Neurother
April 2022
Regional Epilepsy Centre, Great Metropolitan "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy.
Introduction: Status epilepticus (SE) in pregnancy represents a life-threatening medical emergency for both mother and fetus. Pregnancy-related pharmacokinetic modifications and the risks for fetus associated with the use of antiseizure medications (ASMs) and anesthetic drugs complicate SE management. No standardized treatment protocol for SE in pregnancy is available to date.
View Article and Find Full Text PDFDirect Oral Anticoagulants: From Randomized Clinical Trials to Real-World Clinical Practice.
Front Pharmacol
May 2021
Science of Health Department, School of Medicine, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Direct oral anticoagulants (DOACs) are a more manageable alternative than vitamin K antagonists (VKAs) to prevent stroke in patients with nonvalvular atrial fibrillation and to prevent and treat venous thromboembolism. Despite their widespread use in clinical practice, there are still some unresolved issues on optimizing their use in particular clinical settings. Herein, we reviewed the current clinical evidence on uses of DOACs from pharmacology and clinical indications to safety and practical issues such as drugs and food interactions.
View Article and Find Full Text PDFPharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug-Drug Interactions and Tolerability.
CNS Drugs
June 2021
Science of Health Department, University Magna Grecia of Catanzaro, Via T. Campanella, 115, 88100, Catanzaro, Italy.
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be increased to a maximum of 400 mg/day based on clinical response.
View Article and Find Full Text PDFAssessing knowledge and attitudes toward epilepsy among schoolteachers and students: Implications for inclusion and safety in the educational system.
PLoS One
September 2021
Science of Health Department, University Magna Graecia, Catanzaro, Italy.
Several studies have evidenced inadequate knowledge about epilepsy and inappropriate seizure management, influencing quality of life and social inclusion of patients with epilepsy. Aim of the study was to estimate the knowledge and the attitudes toward epilepsy in schoolteachers and students in Italy. Custom-designed and validated questionnaires in Italian on general and specific knowledge, and social impact of epilepsy have been administered in a random sample of schoolteachers and students.
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