AI Article Synopsis
- - The study examines the antitumor effects of polyphenol-rich extracts from thyme-like plants commonly used in Mediterranean food and traditional medicine.
- - The ethanolic extract was effective in inhibiting the growth of various human tumor cell lines while sparing healthy non-cancerous cells.
- - In human breast cancer cells (MCF-7), the extract triggered oxidative stress, increased nitric oxide release, induced apoptosis, and decreased key signaling molecule phosphorylation, suggesting it could be a complementary therapy to enhance conventional cancer treatments.
Article Abstract
Thyme-like plants including . are widely used as food and folk medicinal remedies in the Mediterranean area. This study aimed to explore the in vitro antitumor potential of polyphenol-enriched extracts from aerial parts of . The ethanolic extract significantly inhibited proliferation of different human tumor cell lines, without significant effects on non-neoplastic cells. A deeper investigation of the molecular mechanism sustaining the in vitro antitumor activity of the extract was carried on the human breast cancer cells MCF-7 in comparison with the normal breast cells MCF-10A. The effects on MCF-7 cells were associated with the following: production of reactive oxygen species (ROS) and release of nitric oxide; apoptosis induction; and reduction in STAT3 and NF-kB phosphorylation. The ethanolic extract from leaves might represent a novel therapeutic tool in combination with conventional chemotherapy to reduce the adverse side effects and drug resistance.
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| http://dx.doi.org/10.1080/01635581.2020.1792517 | DOI Listing |
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