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Chromatographic assay of recently approved co-formulation of Vonoprazan fumarate with low dose Aspirin: AGREE, Complex MoGAPI, and RGB 12-model assessments.
BMC Chem
November 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside Green Plaza Complex 21648, Alexandria, Egypt.
Two simple, valid and green chromatographic based techniques are developed in the present work for first time to simultaneously analyze the recently approved combination of Aspirin (ASP) with the novel gastro-protective agent Vonoprazan (VON). First method is an HPLC-DAD "diode array detection", where separation was successful using C18 (250 × 4.6 mm) column with isocratic elution of phosphate buffer-pH 6.
View Article and Find Full Text PDFComprehensive analysis of Aspirin and Apixaban: thedevelopment, validation, and forced degradation studies of bulk drugs and capsule formulations using the RP-HPLC method.
Am J Transl Res
October 2024
Berkshire Sterile Manufacturing Lee, MA, USA.
Objectives: This study aimed to develop a robust Reverse Phase-High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of Aspirin (ASP) and Apixaban (API) in bulk and in-house capsule formulations.
Methods: The separation was conducted on a Phenomenex Luna C column using a Shimadzu LC20AT High-performance liquid chromatography (HPLC) system. The mobile phase consisted of 40:60 Acetonitrile (ACN): phosphate buffer (pH 4) modified by O-Phosphoric Acid (OPA).
125 Years of Aspirin: Status of Analytical Methods.
Curr Pharm Des
October 2024
Department of Pharmacy, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
Article Synopsis
- Aspirin, discovered in 1899 by Felix Hoffman, has been a top-selling drug for 125 years, serving as a major success in the pharmaceutical industry.
- This review highlights various analytical methods used to study Acetylsalicylic Acid (ASA) and their relevance to current sustainable chemistry practices.
- The predominant analytical techniques for ASA are HPLC and UV-Vis, mainly involving traditional solvents like methanol and acetonitrile, suggesting a need for greener solutions in the evaluation of this long-standing medication.
Long-Term Effects of Low-Dose Aspirin on Gastrointestinal Symptoms and Bleeding Complications in Patients with Type 2 Diabetes.
Am J Cardiovasc Drugs
September 2024
Department of Data Science, Hyogo Medical University, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
Article Synopsis
- The JPAD trial studied the long-term effects of low-dose aspirin on gastrointestinal symptoms and bleeding in diabetic patients, comparing those taking aspirin to those not taking it.
- Among 2535 participants, the aspirin group experienced a significantly higher rate of gastrointestinal issues, with 8.8% compared to 5.7% in the no-aspirin group at 18 years.
- The risk was notably higher within the first 3 years, particularly for buffered aspirin, suggesting that these factors should influence decisions on starting and continuing low-dose aspirin for prevention.
Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles.
Curr Drug Deliv
January 2024
Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, 16846-13114, Tehran, Iran.
Introduction: Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic frameworks due to their highly desirable properties, including high surface area, appropriate pore size, and excellent thermal and chemical stability.
Method: In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was utilized as a suitable and effective platform for the drug delivery system. The preparation of this coated MOF followed environmentally friendly methods, and aspirin was successfully loaded.
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