Background: Blockchain has emerged as a decentralized and distributed framework that enables tamper-resilience and, thus, practical immutability for stored data. This immutability property is important in scenarios where auditability is desired, such as in maintaining access logs for sensitive healthcare and biomedical data. However, the underlying data structure of blockchain, by default, does not provide capabilities to efficiently query the stored data. In this investigation, we show that it is possible to efficiently run complex audit queries over the access log data stored on blockchains by using additional key-value stores. This paper specifically reports on the approach we designed for the blockchain track of iDASH Privacy & Security Workshop 2018 competition. In this track, participants were asked to devise an efficient way to run conjunctive equality and range queries on a genomic dataset access log trail after storing it in a permissioned blockchain network consisting of 4 identical nodes, each representing a different site, created with the Multichain platform.
Methods: Multichain duplicates and indexes blockchain data locally at each node in a key-value store to support retrieval requests at a later point in time. To efficiently leverage the key-value storage mechanism, we applied various techniques and optimizations, such as bucketization, simple data duplication and batch loading by accounting for the required query types of the competition and the interface provided by Multichain. Particularly, we implemented our solution and compared its loading and query-response performance with SQLite, a commonly used relational database, using the data provided by the iDASH 2018 organizers.
Results: Depending on the query type and the data size, the run time difference between blockchain based query-response and SQLite based query-response ranged from 0.2 seconds to 6 seconds. A deeper inspection revealed that range queries were the bottleneck of our solution which, nevertheless, scales up linearly.
Conclusions: This investigation demonstrates that blockchain-based systems can provide reasonable query-response times to complex queries even if they only use simple key-value stores to manage their data. Consequently, we show that blockchains may be useful for maintaining data with auditability and immutability requirements across multiple sites.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372773 | PMC |
http://dx.doi.org/10.1186/s12920-020-0721-2 | DOI Listing |
Adv Ther
December 2024
Global Medical and Patient Affairs, Servier, Suresnes, France.
Introduction: The aim of the observational SIMPLE study was to assess real-life effectiveness and safety of a single-pill combination (SPC) of perindopril arginine/amlodipine in a broad range of subjects with newly diagnosed mild-to-moderate hypertension treated in Canadian general practice.
Methods: Treatment-naïve participants aged 18-65 years with mild-to-moderate hypertension, whose physicians decided to initiate the perindopril/amlodipine SPC, were recruited from Canadian clinical practice from October 2017 to February 2019. Participants were followed at 3- (M3) and 6-month (M6) visits after treatment initiation.
Adv Ther
December 2024
GSK, US Value Evidence and Outcomes, Collegeville, PA, 19426-0989, USA.
Introduction: Chronic obstructive pulmonary disease (COPD) is associated with exacerbations which can reduce quality of life and increase mortality. Single-inhaler triple therapy (SITT) is recommended for maintenance treatment of COPD among patients experiencing exacerbations despite dual-therapy use. This real-world comparative effectiveness study compared the impact of SITTs, fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI), and budesonide/glycopyrrolate/formoterol fumarate (BUD/GLY/FORM), on COPD exacerbations and mortality.
View Article and Find Full Text PDFPacing Clin Electrophysiol
December 2024
Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramón Jiménez, Huelva, Spain.
Background: Interventricular dyssynchrony derived from the classic non-physiological stimulation (n-PS) of the right ventricle (RV) is a known cause of left ventricular dysfunction (LVDys).
Methods: This was a prospective descriptive single-center study. We analyzed patients who develop LVDys with n-PS, and the results after upgrading to conduction system pacing (CSP).
Int J Health Plann Manage
December 2024
Centre for Global Chronic Conditions, London School of Hygiene & Tropical Medicine, London, UK.
Background: Reducing inequities in hypertension control among those affected in low- and middle-income countries requires person-centred health system responses based on a contextualised understanding of the choices and care pathways taken by those who rely on the services provided, particularly those from poor and marginalised communities. We examine patterns of care seeking and pathways followed by individuals with hypertension from low-income households in the Philippines and Malaysia. This study aims to fill a significant gap in the literature by analysing the stages at which individuals make decisions that may affect the successful control of their blood pressure.
View Article and Find Full Text PDFJ Autism Dev Disord
December 2024
Department of Psychology, University of Wyoming, Laramie, WY, USA.
Purpose: Autistic adults experience high rates of traumatic events and PTSD. However, little work has evaluated motor vehicle accident (MVA) related trauma symptoms. The goal of this brief report was to provide pilot data characterizing MVA-related peritraumatic reactions, trauma symptoms, and rates of PTSD diagnosis and mental health service use among Autistic compared to non-autistic adults.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!