The literature reports some contradictory results on the degree of phonological specificity of infants' early lexical representations in the Romance language, French, and Germanic languages. It is not clear whether these discrepancies are because of differences in method, in language characteristics, or in participants' age. In this study, we examined whether 12- and 17-month-old French-speaking infants are able to distinguish well-pronounced from mispronounced words (one or two features of their initial consonant). To this end, 46 infants participated in a preferential looking experiment in which they were presented with pairs of pictures together with a spoken word well pronounced or mispronounced. The results show that both 12- and 17-month-old infants look longer at the pictures corresponding to well-pronounced words than to mispronounced words, but show no difference between the two mispronunciation types. These results suggest that, as early as 12 months, French-speaking infants, like those exposed to Germanic languages, already possess detailed phonological representations of familiar words.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/j.1532-7078.2011.00111.x | DOI Listing |
SAGE Open Med Case Rep
August 2024
Department of Cardiovascular Surgery, Kindai University, Osakasayama City, Osaka, Japan.
Herein, we present the case of a 17-month-old boy with asplenia, bilaterally absent pulmonary arteries, and bilateral patent ductus arteriosus, who underwent a successful Fontan operation. The central pulmonary artery was created using a pericardial roll, which was initially oversized due to the elevated pressure from the systemic-to-pulmonary shunt. The size of the roll was reduced through the process of pressure reduction by bidirectional Glenn and Fontan operations.
View Article and Find Full Text PDFLancet Infect Dis
October 2024
Department of Biochemistry and Kavli Institute for Nanoscience Discovery and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. Electronic address:
Background: A blood-stage Plasmodium falciparum malaria vaccine would provide a second line of defence to complement partially effective or waning immunity conferred by the approved pre-erythrocytic vaccines. RH5.1 is a soluble protein vaccine candidate for blood-stage P falciparum, formulated with Matrix-M adjuvant to assess safety and immunogenicity in a malaria-endemic adult and paediatric population for the first time.
View Article and Find Full Text PDFAnim Cells Syst (Seoul)
May 2024
Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea.
The cytoplasmic FMR1-interacting protein 2 (CYFIP2) have diverse molecular functions in neurons, including the regulation of actin polymerization, mRNA translation, and mitochondrial morphology and function. Mutations in the gene are associated with early-onset epilepsy and neurodevelopmental disorders, while decreases in its protein levels are linked to Alzheimer's disease (AD). Notably, previous research has revealed AD-like phenotypes, such as dendritic spine loss, in the hippocampal CA1 pyramidal neurons of 12-month-old heterozygous mice but not of age-matched CA1 pyramidal neuron-specific conditional knock-out (cKO) mice.
View Article and Find Full Text PDFThe use of disinfectants, particularly those containing quaternary ammonium compounds (QUACs), has dramatically escalated globally since the coronavirus disease 2019 pandemic. We report a case that highlights the risks associated with ingesting low-concentration QUAC solutions and emphasize the importance of effective management in resolving severe lesions without sequelae. A 17-month-old boy experienced severe respiratory failure after ingesting a disinfectant containing benzalkonium chloride (BAC).
View Article and Find Full Text PDFMol Genet Genomic Med
January 2024
Department of Cytogenetic Laboratory, Children's Hospital of Shanxi, Women Health Center of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Background: Isoleucinyl-tRNA synthetase (IARS) is encoded by the IARS1 gene and catalyzes the binding of isoleucine to specific tRNA.
Objective: This study aims to investigate the pathogenicity of novel IARS1 variants and the genotype-phenotype association, in order to expand the spectrum of pathogenic variants and phenotypes of IARS1-related disease and provide new evidence for the phenotypic spectrum of IARS1 variants.
Methods: Clinical data of the proband were collected, and trio whole-exome sequencing (WES) was performed on the proband and the parents.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!