During the second year of life, infants develop a preference to attach novel labels to novel objects. This behavior is commonly known as "mutual exclusivity" (Markman, 1989). In an intermodal preferential looking experiment with 19.5- and 22.5-month-olds, stimulus repetition was critical for observing mutual exclusivity. On the first occasion that a novel label was presented with 1 familiar object and 1 novel object, looking behavior was unsystematic. However, on reexposure to the same stimuli, 22.5-month-olds looked preferentially at the novel object prior to the re-presentation of the novel label. These findings suggest a powerful memory mechanism for novel labels and objects, enabling mutual exclusivity to emerge across repeated exposures to potential referents.
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http://dx.doi.org/10.1080/15250000802569702 | DOI Listing |
Hum Mov Sci
January 2025
Department of Sports Rehabilitation, Cheongju University, Republic of Korea. Electronic address:
This study investigated muscle synergies during squats, focusing on the individual variability in motor control strategies. Sixteen healthy young adults performed 20 squats at a consistent speed. Muscle synergies were extracted using non-negative matrix factorization, followed by k-means clustering and discriminant analysis to categorize similar muscle synergies.
View Article and Find Full Text PDFEur Urol Open Sci
January 2025
Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Background And Objective: Radiation-induced cystitis (RIC) is an important consequence of pelvic radiotherapy that can cause high morbidity and, in extreme cases, mortality. The lack of a widely accepted classification system makes it difficult to compare treatment regimens. Our aim was to develop a new classification system covering the RIC spectrum to improve treatment comparisons and accurate incidence estimates for systematic use in clinical and research settings.
View Article and Find Full Text PDFPathol Oncol Res
January 2025
Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
The () gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins. Pan-TRK antibody, which shows the overexpression of the genes, is a useful tool to detect tumors with or without gene alterations, due to high negative predictive value. Though it is well known that pan-TRK immunopositivity is usually not connected to fusion, the role of other possible genetic alterations is under-researched.
View Article and Find Full Text PDFNat Commun
January 2025
Institute for Experimental Medicine, Kiel University, Kiel, Germany.
Bacterial type VI secretion systems (T6SSs) are puncturing molecular machines that transport effector proteins to kill microbes, manipulate eukaryotic cells, or facilitate nutrient uptake. How and why T6SS machines and effectors differ within a species is not fully understood. Here, we applied molecular population genetics to the T6SSs in a global population of the opportunistic pathogen Pseudomonas aeruginosa.
View Article and Find Full Text PDFGenome Biol
January 2025
Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Centre National de La Recherche Scientifique (CNRS), Commissariat À L'EnergieAtomique (CEA), Gif-Sur-Yvette, 91190, France.
Background: The DNA/H3K9 methylation and Polycomb-group proteins (PcG)-H3K27me3 silencing pathways have long been considered mutually exclusive and specific to transposable elements (TEs) and genes, respectively in mammals, plants, and fungi. However, H3K27me3 can be recruited to many TEs in the absence of DNA/H3K9 methylation machinery and sometimes also co-occur with DNA methylation.
Results: In this study, we show that TEs can also be solely targeted and silenced by H3K27me3 in wild-type Arabidopsis plants.
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