Objective: Advanced age is accompanied by a deterioration in memory performance that can profoundly influence activities of daily living. However, the neural processes responsible for age-related memory decline are not fully understood. Here, we used transcranial magnetic stimulation (TMS) in combination with electroencephalography (EEG) to assess age-related changes in neuroplasticity in the human prefrontal cortex.
Methods: TMS-evoked cortical potentials (TEPs) were recorded before and following the neuroplasticity-inducing intermittent theta burst stimulation (iTBS), applied to the left lateral prefrontal cortex in healthy young (n = 33, mean age 22 ± 3 years) and older adults (n = 33, mean age 68 ± 7 years).
Results: iTBS increased the amplitude of the positive TEP component at 60 ms after the TMS pulse (P60) in young, but not older adults. This age-related decline in P60 plasticity response was associated with poorer visuospatial associative (but not working) memory performance in older adults.
Conclusions: These findings suggest that neuroplasticity in the human lateral prefrontal cortex is reduced in older relative to young adults, and this may be an important factor in age-related memory decline.
Significance: This may have important implications for the early detection of cognitive decline and dementia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinph.2020.06.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.
BMC Psychiatry
December 2024
Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Background: The clinical characteristics of major depressive disorder (MDD) in adolescents show notable gender-related differences, but the cause of these differences is still not understood. The current research concentrates on the changes in neurometabolism and neuroendocrine function, aiming to identify differences in endocrine function and brain metabolism between male and female adolescents with MDD.
Methods: A total of 121 teenagers diagnosed with MDD (43 males and 78 females) were enlisted as participants.
Research Review: Shared and distinct structural and functional brain alterations in adolescents with major depressive disorder' - a multimodal meta-analysis.
J Child Psychol Psychiatry
December 2024
Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
Background: Neuroimaging studies have identified brain structural and functional alterations in adolescents with major depressive disorder (MDD); however, the results are inconsistent, and whether patients exhibit spatially convergent structural and functional brain abnormalities remains unclear.
Methods: We conducted voxel-wise meta-analysis of voxel-based morphometry (VBM) and resting-state functional studies, respectively, to identify regional gray matter volume (GMV) and brain activity alterations in adolescent MDD patients. Multimodal analysis was performed to examine the overlap of regional GMV and brain activity alterations.
Brain Functional Characteristics in Football Players During Motor-Cognitive Dual Task: Insights From fNIRS.
Scand J Med Sci Sports
January 2025
School of Physical Education, Shanghai University of Sport, Shanghai, China.
Long-term training enables professional athletes to develop concentrated and efficient neural network organizations for specific tasks. This study used functional near-infrared spectroscopy to investigate task performance, brain functional characteristics, and their relationships in footballers during sport-specific motor-cognitive processes. Twenty-four footballers (athlete group, with 18 remaining of good signal quality) and 20 non-footballers (control group, with 16 remaining) completed four tasks: a single task (trigger buttons corresponding to the appearance direction of teammates with kicking actions), an N-back direction task, a dual task, and an N-back digit task.
View Article and Find Full Text PDFMajor Depressive Disorder (MDD) poses a significant public health challenge due to its high prevalence and the substantial burden it places on individuals and healthcare systems. Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) shows promise as a treatment for this disorder, although its mechanisms of action remain unclear. This study investigated whole-brain response patterns during rtfMRI-NF training to explain interindividual variability in clinical efficacy in MDD.
View Article and Find Full Text PDFNegative valence in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.
Biol Psychiatry
December 2024
Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands.
Objective: Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled fMRI data of 633 individuals with OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.
Methods: Participant data were processed uniformly using HALFpipe, to extract voxelwise participant-level statistical images of one common first-level contrast: negative vs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!