AI Article Synopsis
- Hematopoietic stem cells (HSCs) have unique metabolic needs that change as they move through different developmental stages and tissues.
- Understanding how HSCs adapt their metabolism is critical, especially since these changes support their role in blood cell formation (hematopoiesis).
- This review focuses on the importance of mitochondrial metabolism in determining HSC fate and explores the relationships between mitochondria, endoplasmic reticulum, and lysosomes in their metabolic processes.
Article Abstract
Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418032 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2020.06.029 | DOI Listing |
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