Combinational administration of photothermal therapy (PTT) and chemotherapy (CT) shows great potential in improving the efficiency of tumor treatment. Herein, we designed a novel nanocomposite Pt@BiTe composed of bismuth telluride (BiTe) nanoparticles and platinum(IV) prodrugs (Pt) for PTT-CT combination therapy. The obtained BiTe was synthesized by a simple solvothermal method and modified by polyethylene glycol, which exhibited excellent photothermal (PT) efficiency and stability and could also serve as a bimodal bioimaging contrast agent in PT and photoacoustic (PA) imaging. experiment results showed that the nanocomposite Pt@BiTe could effectively increase the uptake of platinum in cancer cells, which could kill tumor cells through the combined effect of PTT and CT. Furthermore, combination therapy of cancer was achieved with obvious tumor-growth inhibition without inducing observed side effects. We revealed the great potential of BiTe nanocomposites in increasing therapeutic efficiency by PTT-CT therapy and PA-PT imaging.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00458DOI Listing

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