AI Article Synopsis
- The rise of multidrug-resistant microorganisms has led researchers to explore new antimicrobial approaches, focusing on antivirulence strategies to reduce drug resistance.
- A total of 22 quorum sensing inhibitors were created by mimicking the structure of certain natural compounds.
- One inhibitor showed a 34% reduction in biofilm formation and enhanced the effectiveness of Gentamycin sulfate by inhibiting extracellular polysaccharides.
Article Abstract
The emergence of multidrug resistant microorganisms has triggered the impending need for new aitimicrobial strategies. The antivirulence strategy with the benefite of alleviating the drug resistance becomes the focus of research. In this study, 22 quorum sensing inhibitors were synthesized by mimicking the structure of autoinducer and acinetobactin and up to 34% biofilm inhibition was observed with 5u. The biofilm inhibition effect was further demonstrated with extracellular polysaccharides inhibition and synergism with Gentamycin sulphate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2020.115606 | DOI Listing |
Publication Analysis
Top Keywords
biofilm inhibition
8
synthesis antibiofilm
4
antibiofilm evaluation
4
evaluation 3-hydroxy-23-dihydroquinazolin-41h-one
4
3-hydroxy-23-dihydroquinazolin-41h-one derivatives
4
derivatives opportunistic
4
opportunistic pathogen
4
pathogen acinetobacter
4
acinetobacter baumannii
4
baumannii emergence
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!