AI Article Synopsis
- Technical limitations and clinical challenges previously hindered effective surgical management of epilepsy, but recent technological advancements show promise for better outcomes and reduced patient complications.! -
- Innovations in neurosurgery for epilepsy include wireless recording systems, advanced electrodes, robot-assisted surgery, optogenetics, novel PET ligands, and focused ultrasonography.! -
- Research into the genetic aspects of epilepsy is paving the way for precision medicine, enabling personalized treatment plans, better understanding of underlying mechanisms, and enhanced selection of effective interventions.!
Article Abstract
Technical limitations and clinical challenges have historically limited the diagnostic tools and treatment methods available for surgical approaches to the management of epilepsy. By contrast, recent technological innovations in several areas hold significant promise in improving outcomes and decreasing morbidity. We review innovations in the neurosurgical management of epilepsy in several areas, including wireless recording and stimulation systems (particularly responsive neurostimulation [NeuroPace]), conformal electrodes for high-resolution electrocorticography, robot-assisted stereotactic surgery, optogenetics and optical imaging methods, novel positron emission tomography ligands, and new applications of focused ultrasonography. Investigation into genetic causes of and susceptibilities to epilepsy has introduced a new era of precision medicine, enabling the understanding of cell signaling mechanisms underlying epileptic activity as well as patient-specific molecularly targeted treatment options. We discuss the emerging path to individualized treatment plans, predicted outcomes, and improved selection of effective interventions, on the basis of these developments.
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| http://dx.doi.org/10.1016/j.wneu.2020.03.031 | DOI Listing |
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