Rodlike molecules in extreme confinement.

A unique feature of colloid particles and biopolymers is the molecule's intrinsic rigidity characterized by a molecular-level length scale. Under extreme confinement conditions at cellular scales or in nanodevices, these molecules can display orientational ordering accompanied by severe density depletion. Conventional liquid-crystal theories, such as the Oseen-Frank or Landau-de Gennes theories, cannot capture the essential molecular-level properties: the boundary effects, which extend to a distance of the rigidity length scale, and the drastic variations of the inhomogeneous molecular density. Here we show, based on a simple interpretation of the Onsager model, that rodlike molecules in extreme annular confinement produce unusual liquid-crystal defect structures that are independent phases from the patterns usually seen in a weaker confinement environment.