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Nucleus pulposus cell-mimicking nanoparticles for cell-specific HIF1A editing to modulate SASP-mediated disc inflammation via autophagy activation.
Acta Biomater
March 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Traditional methods of plasmid delivery, including viral vectors, lipofection, and electroporation, are widely used for gene editing but have limitations, such as cellular toxicity, limited transfection efficiency in primary cells, and nonspecific side effects. Here, we report the development of nucleus pulposus cell (NPC)-mimicking nanoparticles (HIF1A@NNP) with an NPC membrane as the shell and pcDNA3.1-rHIF1A encapsulated in the core via extrusion.
View Article and Find Full Text PDFRisk of acute kidney injury after percutaneous coronary intervention with plaque modification.
Cardiovasc Revasc Med
March 2025
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:
Background: The use of plaque modification techniques during percutaneous coronary interventions (PCI) has increased. However, these procedures are linked to higher contrast volume and hypotensive episodes, which are risk factors for acute kidney injury (AKI). This study examined the effects of various plaque modification techniques on AKI after PCI.
View Article and Find Full Text PDFPHEMI-Phenylbutyrate in Patients With Lactic Acidosis: A Pilot, Single Arm, Phase I/II, Open-Label Trial.
Clin Ther
March 2025
Fondazione IRCCS Istituto Neurologico Carlo Besta, Medical Genetics and Neurogenetics Unit, Milan, Italy. Electronic address:
Purpose: The 6 months pilot, single arm, phase I/II, open-label clinical trial PHEMI investigated the safety and efficacy of daily administration of phenylbutyrate in reducing lactic acidosis by at least 20% in 3 children (ages 7-10 yrs) with pyruvate dehydrogenase deficiency and 6 adults with mitochondrial myopathy encephalopathy lactic acidosis and stroke-like episodes. As a side study, we investigated the response to phenylbutyrate treatment in skin fibroblasts and cybrids derived from PHEMI patients with the aim of unraveling a possible in vivo-in vitro correlation.
Methods: Safety was assessed through the collection of vital signs, clinical evaluations, blood samples, and reported adverse events.
Well-being scarring effects of college non-completion.
Soc Sci Res
March 2025
University of Hamburg, Germany.
Little is known about the socio-emotional consequences of dropping out of college. Here, we investigate the effects of college non-completion on a range of markers for general psychological well-being (self-esteem, life satisfaction, and fear of failure) as well as health-related well-being (self-rated general health and clinical depressive symptoms). Based on rich panel data from Germany in combination with entropy balancing, we find that by around age 31, non-completers fared worse compared to college graduates as well as non-college goers, i.
View Article and Find Full Text PDFThe effect of gender role stress on psychological distress in pregnant women.
Appl Nurs Res
April 2025
Department of Nursing, Health Sciences Institute, Sakarya University, Serdivan, Sakarya, Turkey. Electronic address:
Aim: To examine the effect of gender role stress on psychological distress in pregnant women.
Background: Recognition and prevention of potential psychological as well as physiological adversities during pregnancy are critical in terms of reducing their impacts on mother and baby health and developing preventive health services.
Methods: This cross-sectional study was conducted with 182 volunteer pregnant women in Türkiye.
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