AI Article Synopsis
- The issue of diagnosing acute and fatal poisoning from hellebore, commonly used in traditional medicine, is still a major concern due to misusage in food or preparations.
- There is currently no standardized method for diagnosing such poisoning in forensic and toxicological labs, making reliance on patient history the norm.
- The study highlights the need for a reliable method to detect hellebore alkaloids in biological samples, recommending HPLC-MS/MS as the most effective technique for its high sensitivity and specificity.
Article Abstract
The problem of laboratory diagnosis of acute and fatal poisoning by hellebore, which is possible when used in traditional medicine, the erroneous use of hellebore preparations orally or use of various types of this plant for food, remains relevant. Currently, in the practice of chemical-toxicological laboratories and the bureau of forensic medical examination there is no single approach to the laboratory diagnosis of such poisoning. The diagnosis is most often based on anamnesis. In this regard, the development and validation of a legally significant methodology for the determination of hellebore alkaloids in various biological objects seems relevant. The physicochemical and toxic properties of alkaloids of various types of hellebore are characterized. It was shown that for the identification of hellebore alkaloids, it is advisable to use HPLC-MS/MS as the most sensitive and specific instrumental method corresponding to the characteristics of hellebore alkaloids (high molecular weight, high thermal lability, high polarity).
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| http://dx.doi.org/10.17116/sudmed20206304134 | DOI Listing |
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Article Synopsis
- The issue of diagnosing acute and fatal poisoning from hellebore, commonly used in traditional medicine, is still a major concern due to misusage in food or preparations.
- There is currently no standardized method for diagnosing such poisoning in forensic and toxicological labs, making reliance on patient history the norm.
- The study highlights the need for a reliable method to detect hellebore alkaloids in biological samples, recommending HPLC-MS/MS as the most effective technique for its high sensitivity and specificity.
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