Black liquor, a residual stream from the Kraft recovery process of paper mills is an incipient biomass energy resource which finds prospective biofuel-based industrial applications to ensure process self-sufficiency and sustainability. Black liquor is concentrated using Multiple Stage Evaporator, the utmost energy intensive unit, before using it as biofuel. Pertaining to the contemporary global energy scenario, improvement in energy efficiency of Multiple Stage Evaporator becomes indispensable. The present work investigates the non-linear modeling and simulation-based optimization of Heptads' stage based Multiple Stage Evaporator in backward feed flow configuration integrated with various energy saving strategies. A novel metaheuristic approach, Water Cycle Algorithm has been employed to search the optimum estimates of unknown process variables and therefore, the optimum energy efficiency parameters. The optimization results demonstrate the efficiency of Water Cycle Algorithm in screening the most appropriate operating strategy, , hybrid model of all energy saving strategies (steam-split, feed-split and feed-preheating) with optimum energy efficiency Steam Economy of 7.092 and Steam Consumption of 1.919 kg/s. Moreover, a comparative analysis of the results with previous literature and real-time plant estimates reveal that the hybrid model offers improvement of 52.84% in Steam Economy and reduction in Steam Consumption by 28.13% when compared to the real plant data.
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http://dx.doi.org/10.1016/j.heliyon.2020.e04349 | DOI Listing |
S Afr J Surg
December 2024
Department of Surgery, University of KwaZulu-Natal, South Africa.
Background: This study aimed to assess the contribution of human error to adverse events over 10 years in a single surgical department in South Africa.
Methods: A retrospective database analysis was undertaken to identify all adverse events, which were further assessed to identify which were error-associated.
Results: A total of 14 237 adverse events occurred between December 2012 and January 2023, of which 7 504 (52.
Front Oncol
January 2025
Department of Nuclear Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Intrahepatic cholangiocarcinoma (ICC)originates from the epithelial cells of the intrahepatic bile ducts, with insidious onset and strong invasiveness, and most of the cases are found in the advanced stage, with extremely poor prognosis. In advanced stages, distant metastases to the lungs, bones, and brain are common, but distant soft tissue (subcutaneous and skeletal muscle) and breast metastases are rare, and simultaneous metastases to all three rare sites had not been reported. We report a 69-year-old woman with right upper abdominal pain who underwent a plain and enhanced CT scan of the upper abdomen, which revealed an intrahepatic space-occupying lesion, as well as subcutaneous and peritoneal nodules in the abdomen.
View Article and Find Full Text PDFBMJ Oncol
January 2024
Novelna Inc, Palo Alto, California, USA.
Objective: Early detection of cancer is crucial for reducing the global burden of cancer, but effective screening tests for many cancers do not exist. This study aimed to develop a novel proteome-based multi-cancer screening test that can detect early-stage cancers with high accuracy.
Methods And Analysis: We collected plasma samples from 440 individuals, healthy and diagnosed with 18 early-stage solid tumours.
BMJ Oncol
August 2024
Technology & Innovation Center, GE HealthCare, Niskayuna, NY, USA.
Objective: Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multiple apoptosis pathway proteins at single cell level and determine multi-protein associations with recurrence risk and chemotherapy response in patients with stage II colorectal cancer (CRC).
Methods And Analysis: Multiplexed imaging of 16 proteins in the intrinsic and extrinsic apoptosis pathways at single cell resolution on resected tissue from 194 patients with stage II CRC who either received adjuvant chemotherapy (n108) or were treated with surgery only (n=86).
Expert Opin Drug Saf
January 2025
Department of Pharmacy, Xi' an Central Hospital, Xi'an, Shaanxi, China.
Objective: The FDA Adverse Event Reporting System (FAERS) was used to evaluate the associations between oral anticoagulants (OACs) and acute kidney injury (AKI).
Methods: Disproportionality analysis were applied to data in the FAERS database from January 2004 to December 2023 to detect adverse events (AEs) for various OACs. The adjusted reporting odds ratios (RORs) calculated using multiple logistic regression were used to explore the risk factors for OACs-associated AKI.
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