AI Article Synopsis
- A retrospective RT-PCR test for SARS-CoV-2 was conducted on frozen samples from patients with respiratory infections in Western Switzerland, specifically from November 2019 to March 2020.! -
- No cases of SARS-CoV-2 were found before the first officially reported cases, indicating no undetected infections in that period.! -
- The study implies that the targeted screening strategy used was effective, particularly given the challenges in increasing testing availability at the time.!
Article Abstract
• Retrospective RT-PCR was performed for SARS-CoV-2 on frozen nasopharyngeal swabs of patients with lower respiratory tract infections collected in Western Switzerland between November 2019 and March 2020. • No case was identified before the first officially diagnosed cases. • This suggests that the targeted screening approach was adequate when faced with difficulties in upscaling testing capacity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365111 | PMC |
| http://dx.doi.org/10.1016/j.ijantimicag.2020.106100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Scent dogs identify SARS-CoV-2-infections in respiratory samples from experimentally infected ferrets and hamsters-a pilot study.
Front Med (Lausanne)
December 2024
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
Rapid and sensitive diagnostic measures are a pre-requisite for the control of SARS-CoV-2 outbreaks. Dogs detect SARS-CoV-2-infected human individuals with high speed due to their extraordinary olfactory acuity. In the post-pandemic phase of SARS-CoV-2 it is difficult to obtain samples from infected humans for scent dog training.
View Article and Find Full Text PDFThe Open Hand Initiative: Facilitating the Use of Real-World Evidence in Regulatory Submissions Through Collaboration and Transparency.
Clin Pharmacol Ther
December 2024
Becton Dickinson, Sparks, Maryland, USA.
Real-world data (RWD) collected to generate real-world evidence (RWE) holds promise for expediting patient and healthcare provider access to new in vitro diagnostics (IVDs) by serving as evidence to demonstrate test performance or utility. However, uncertainties remain for IVD developers (device manufacturers), regulators, and other healthcare stakeholders on the specifics of collecting fit-for-purpose RWD and using RWE for regulatory decision-making. We report on a unique approach to medical device regulatory review called the Open Hand Initiative, by which the US Food and Drug Administration (FDA) and device manufacturers collaborate to ensure the appropriate use of RWD/RWE to support regulatory decision-making.
View Article and Find Full Text PDFWhy are people with dementia overlooked in long-term care insurance policy in Guangzhou, China?
BMC Health Serv Res
December 2024
Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, No. 74, Zhongshan 2 Road, Guangzhou, China.
Background And Objectives: There is a growing demand for dementia care to be funded by long-term care insurance (LTCI). However, evidence indicates that people with dementia are overlooked in China's LTCI policy and empirical research on this issue is notably scarce. Among the first seven LTCI pilot cities that officially enrolled people with dementia, Guangzhou is unique for roll-back LTCI policies related to eligibility criteria and benefits.
View Article and Find Full Text PDFTackling persistent neurological symptoms in patients following acute COVID-19 infection: an update of the literature.
Expert Rev Neurother
December 2024
Department of Neurology, Loyola University Stritch School of Medicine, Loyola University Health System, Maywood, IL, USA.
Introduction: The COVID-19 pandemic has taught myriad lessons and left several questions we are yet to comprehend. Initially, the scientific community was concerned with the management of acute disease and immunization. Once the peak of the pandemic receded, it became clear that a proportion of patients were far from fully recovered.
View Article and Find Full Text PDFSARS-CoV-2 Spike S1 subunit triggers pericyte and microvascular dysfunction in human pancreatic islets.
Diabetes
December 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine.
The COVID-19 pandemic has profoundly affected human health, yet the mechanisms underlying its impact on metabolic and vascular systems remain incompletely understood. Clinical evidence suggests that SARS-CoV-2 directly disrupts vascular homeostasis, with perfusion abnormalities observed in various tissues. The pancreatic islet, a key endocrine mini-organ reliant on its microvasculature for optimal function, may be particularly vulnerable.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!