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Androgen-receptor-positive hepatocellular carcinoma in a transgender teenager taking exogenous testosterone.
Lancet
July 2020
Department of Radiation Oncology, Washington University in Saint Louis, Saint Louis, MO, USA. Electronic address:
Inhibition of growth and induction of TGF-beta 1 in human hepatocellular carcinoma with androgen receptor by cyproterone acetate in male nude mice.
J Hepatol
October 1996
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Background/aims: Hepatocellular carcinoma possesses androgen receptor but its true role is not known. This study aimed to investigate the effect of an anti-androgen cyproterone acetate on the growth of androgen receptor-positive hepatocellular carcinoma.
Methods: Androgen receptor-positive human hepatocellular carcinoma cells (KYN-1/SM-10) were subcutaneously transplanted into male nude mice.
Androgen and oestrogen receptors in hepatocellular carcinoma and surrounding liver parenchyma: impact on intrahepatic recurrence after hepatic resection.
Br J Surg
April 1995
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Seventy-eight patients in whom androgen or oestrogen receptors, or both, were assayed in hepatocellular carcinoma (HCC) and the surrounding liver were discharged from hospital after curative resection of the tumour. Intrahepatic recurrence was evaluated retrospectively after 28-128 months follow-up to determine the association with receptor status. Androgen and oestrogen receptors in HCC significantly influenced the intrahepatic recurrence rate.
View Article and Find Full Text PDFEffect of androgens and their manipulation on cell growth and androgen receptor (AR) levels in AR-positive and -negative human hepatocellular carcinomas.
J Hepatol
March 1995
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Background/aims: Little is known about genuine roles of androgens and their receptor in hepatocellular carcinoma.
Methods: In the present study, two sublines derived from a human hepatocellular carcinoma cell line KYN-1 were used: KYN-1/SM10 with androgen receptor and KYN-1/SM2 without androgen receptor.
Results: The binding assay with 3H-R1881 identified the presence of both cytosolic and nucleosolic androgen receptors in KYN-1/SM10 but not in KYN-1/SM2.
Sex hormone receptors in hepatocellular carcinoma. Is there a rationale for hormonal treatment?
J Hepatol
February 1993
Liver Unit, Hospital Clínic i Provincial, University of Barcelona, Spain.
The present study assessed the tumor concentration of receptors for estrogens, progesterone and androgens in a series of Western patients with hepatocellular carcinoma. Receptors for estrogens and for progesterone were determined by enzyme immunoassay, while androgen receptors were determined by receptor binding assay. Receptors for progesterone were always absent.
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