Emerging threats such as climate change and urbanisation pose an unprecedented challenge to the integrated management of urban wastewater systems, which are expected to function in a reliable, resilient and sustainable manner regardless of future conditions. Traditional long term planning is rather limited in developing no-regret strategies that avoid maladaptive lock-ins in the near term and allow for flexibility in the long term. In this study, a novel adaptation pathways approach for urban wastewater management is developed in order to explore the compliance and adaptability potential of intervention strategies in a long term operational period, accounting for different future scenarios and multiple performance objectives in terms of reliability, resilience and sustainability. This multi-criteria multi-scenario approach implements a regret-based method to assess the relative performance of two types of adaptation strategies: (I) standalone strategies (i.e. green or grey strategies only); and (II) hybrid strategies (i.e. combined green and grey strategies). A number of adaptation thresholds (i.e. the points at which the current strategy can no longer meet defined objectives) are defined to identify compliant domains (i.e. periods of time in a future scenario when the performance of a strategy can meet the targets). The results obtained from a case study illustrate the trade-off between adapting to short term pressures and addressing long term challenges. Green strategies show the highest performance in simultaneously meeting near and long term needs, while grey strategies are found less adaptable to changing circumstances. In contrast, hybrid strategies are effective in delivering both short term compliance and long term adaptability. It is also shown that the proposed adaption pathways method can contribute to the identification of adaptation strategies that are developed as future conditions unfold, allowing for more flexibility and avoiding long term commitment to strategies that may cause maladaptation. This provides insights into the near term and long term planning of ensuring the reliability, resilience and sustainability of integrated urban drainage systems.
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http://dx.doi.org/10.1016/j.watres.2020.116013 | DOI Listing |
J Cardiothorac Surg
January 2025
Cerrahpasa Medical Faculty, Department of Cardiovascular Surgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Objectives: Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biological glue and felt to repair the proximal anastomotic site, on the outcomes of patients with acute type A aortic dissection.
Methods: A total of 108 patients who underwent surgery for acute type A aortic dissection at our clinic between 2007 and 2020 were included in the study.
Immun Ageing
January 2025
State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.
Background: Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. Despite receiving HAART, immune reconstitution is not fully optimized. The objective of this study was to investigate the impact of aging and HAART on T cell subsets and function in PLWH across different age groups, thereby providing novel insights into the prognosis of older PLWH.
View Article and Find Full Text PDFCardiovasc Diabetol
January 2025
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Rd, Xicheng District, Beijing, 100037, People's Republic of China.
Background: Remnant cholesterol (remnant-C) contributes to atherosclerotic cardiovascular disease (ASCVD), particularly in individuals with impaired glucose metabolism. Patients with impaired glucose metabolism and ASCVD remain at significant residual risk after coronary artery bypass grafting (CABG). However, the role of remnant-C in this population has not yet been investigated.
View Article and Find Full Text PDFJ Neuroinflammation
January 2025
Department of Neuroscience and Experimental Therapeutics, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807-3260, USA.
Background: Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cognitive decline during aging. The present study examined the role of immune cell activation and inflammation in the link between circadian rhythm dysregulation and cognitive impairment in aging.
Methods: C57Bl/6J mice were exposed to shifted light-dark (LD) cycles (12 h advance/5d) during early adulthood (from ≈ 4-6mo) or continuously to a "fixed" LD12:12 schedule.
J Med Case Rep
January 2025
Cardiac Surgery Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Cardiac tamponade is a life-threatening condition resulting from fluid accumulation in the pericardial sac, leading to decreased cardiac output and shock. Various etiologies can cause cardiac tamponade, including liver cirrhosis, which may be induced by autoimmune hepatitis. Autoimmune hepatitis is a chronic inflammatory liver disease characterized by interface hepatitis, elevated transaminase levels, autoantibodies, and increased immunoglobulin G levels.
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