Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
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http://dx.doi.org/10.1093/cid/ciaa948 | DOI Listing |
Nat Commun
December 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology.
View Article and Find Full Text PDFFront Immunol
December 2024
Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
The gut microbiota influences the reactivity of the immune system, and has emerged as an anti-inflammatory commensal. Here, we investigated whether its lysate could prevent severe forms of neuroinflammation in experimental autoimmune encephalomyelitis (EAE) in mice and how this preventive strategy affects the gut microbiota and immune response. Lysate of anaerobically cultured (Pd lysate) was orally administered to C57BL/6 mice in four weekly doses.
View Article and Find Full Text PDFFront Microbiol
December 2024
College of Life Sciences, Tianjin Normal University, Tianjin, China.
The gut microbiota of migratory birds is influenced by their food choices, and exploring the potential relationship between diet composition and gut microbiota can help better protect related species. By integrating non-invasive sampling techniques, high-throughput sequencing technology, and microscopic examination technology, this study presents the first evidence on diet composition during overwintering periods as well as the potential relationship between diet composition and gut microbiota in wild relict gulls (). Thirty-five fecal samples from two consecutive overwintering periods (2021 and 2022 overwintering periods) in Tianjin coastal wetland were used to investigate inter-year consistencies and discrepancies on diet composition and gut microbiota in wild It was found that the common dominant phyla of both 2021 and 2022 group included Firmicutes, Proteobacteria, Chloroflexi and Actinobacteriota.
View Article and Find Full Text PDFFront Microbiol
December 2024
Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, China.
Introduction: Atopic dermatitis (AD) is an allergic disease caused by various factors that can affect an individual's appearance and cause psychological stress. Therefore, it is necessary to investigate the underlying mechanisms and develop effective treatment strategies. The gut microbiota and bacterial metabolism play crucial roles in human diseases.
View Article and Find Full Text PDFOncol Lett
March 2025
Department of Geriatrics, Harbin 242 Hospital, Harbin, Heilongjiang 150060, P.R. China.
Sarcopenia is an age-related disease that is characterized by a decline in muscle mass and function with significant epidemiological and clinical implications. In recent years, gut microbiota has gained attention as an important regulatory factor in human health. To the best of our knowledge, this is the first study to introduce the definition and epidemiological background of sarcopenia and analyze the potential impact of the gut microbiota on muscle metabolism and growth, including aspects such as gut microbiota metabolites, muscle protein synthesis and energy metabolism.
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