AI Article Synopsis
- Safinamide (SF) is a medication that helps manage symptoms in fluctuating Parkinson's disease (PD) patients, particularly when combined with levodopa, but there's limited research on its effects in older patients.
- This study examined the outcomes of adding SF to the treatment of 53 PD patients over 65 years old, with some taking 50 mg and others 100 mg for at least 6 months.
- Results showed that SF was well tolerated, with only 30% experiencing adverse events and 60% reporting improved symptoms, indicating its efficacy and safety in elderly patients.
Article Abstract
Safinamide (SF) is a third-generation monoamine-oxidase-B inhibitor that proved efficacy as add-on to levodopa in fluctuating Parkinson's disease (PD) patients. Despite the high prevalence of complicated PD in older population, the data on the tolerability, safety and efficacy of SF in elderly patients are rather poor. Here we studied retrospectively the consequences of add-on with SF in PD patients older than 65 years. Fifty-three fluctuating PD patients were included (30 subjects aged between 65 and 75 years, the remaining 23 subjects aged > 75 years). Patients were treated with either 50 (n = 27) or 100 mg (n = 26) SF for at least 6 months. In all patients, fluctuations were identified by the report of a Wearing-Off-Questionnaire-19 (WOQ-19) score ≥ 3 at baseline. Add-on with SF was well tolerated and safe. Adverse events occurred in 30% of patients and led to drug discontinuation in 11% of cases. At follow-up visits, 60% of patients reported lowering of the WOQ-19 score to ≤ 2. There were no significant differences related to age or daily drug dose in tolerability, safety or efficacy. The results of this study provide evidence of the efficacy, tolerability and safety of SF in elderly PD patients.
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| http://dx.doi.org/10.1007/s40520-020-01648-3 | DOI Listing |
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