We demonstrate quantum cascade laser (QCL) optical frequency combs emitting at λ ∼ 6 μm. A 5.5 μm-wide, 4.5 mm-long laser exhibits comb operation from -20 °C up to 50 °C. A maximum output power of 300 mW is achieved at 50 °C showing a robustness of the system. The laser output spectrum is ∼80 cm wide at the maximum current, with a mode spacing of 0.334 cm, resulting in a total of 240 modes with an average power of 0.8 mW per mode. To achieve frequency comb operation, a plasmonic-waveguide approach is utilized. A thin, highly-doped indium phosphide (InP) layer is inserted in the top cladding design to compensate the positive dispersion of the system (material and waveguide). This approach can be further exploited to design QCL combs at even shorter wavelengths, down to 4 μm. Different ridge widths between 2.8 and 5.5 μm have been fabricated and characterized. All of the devices exhibit frequency comb operation. These observations demonstrate that the plasmonic-waveguide is a robust and reliable method for dispersion compensation of a semiconductor laser systems to achieve frequency comb operation.
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http://dx.doi.org/10.1364/OE.395260 | DOI Listing |
Comb Chem High Throughput Screen
January 2025
Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, China.
Aims And Objectives: This study aimed to explore the relationship between HERC6- associated immune response and Non-Alcoholic Fatty Liver Disease (NAFLD) and to screen drug candidates for novel treatments.
Materials And Methods: Mendelian Randomization (MR) was performed to test the relationship between a genetically predicted increase in HERC6 expression and the development of NAFLD. A single-cell RNA-seq profile of liver tissue with histological characteristics (GSE168933) was obtained.
Comb Chem High Throughput Screen
December 2024
Department of General Surgery, the Second Hospital of HeBei Medical University, Shijiazhuang, China.
Background: SH2B adaptor protein 2 (SH2B2, also named APS) is an adaptor protein implicated in the modulation of insulin signaling pathways and glucose metabolism. Its role in colon adenocarcinoma (COAD) is unknown.
Methods: Data from The Cancer Genome Atlas and Gene Expression Omnibus database were utilized to assess SH2B2 expression and its clinical significance in COAD.
Sensors (Basel)
November 2024
Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Monitoring the dynamic behaviors of self-aligning roller bearings (SABs) is vital to guarantee the stability of various mechanical systems. This study presents a novel self-powered, intelligent, and self-aligning roller bearing (I-SAB) with which to monitor rotational speeds and bias angles; it also has an application in fault diagnosis. The designed I-SAB is compactly embedded with a novel sweep-type triboelectric nanogenerator (TENG).
View Article and Find Full Text PDFTrends Hear
December 2024
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
In open-fit digital hearing aids (HAs), the processing delay influences comb-filter effects that arise from the interaction of the processed HA sound with the unprocessed direct sound. The current study investigated potential relations between preferred processing delay, spectral and temporal processing abilities, and self-reported listening habits. Ten listeners with normal hearing and 20 listeners with mild-to-moderate sensorineural hearing impairments participated.
View Article and Find Full Text PDFComb Chem High Throughput Screen
December 2024
Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Background: Necroptosis, a recently identified mechanism of programmed cell death, exerts significant influence on various aspects of cancer biology, including tumor cell proliferation, stemness, metastasis, and immunosuppression. However, the role of necroptosis-related genes (NRGs) in Hepatocellular Carcinoma (HCC) remains elusive.
Methods: In this study, we assessed the mutation signature, copy number variation, and expression of 37 NRGs in HCC using the TCGA-LIHC dataset.
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