It is shown that the reservoir engineering can be controlled by the collective phase Φ of three coherent fields interacting with a closed Δ-type atom. We find that the atomic system acts as a one-channel dissipation reservoir when Φ = 0(π), but it behaves as a two-channel dissipation reservoir for Φ ≠ 0(π). The phase-dependent reservoir engineering provides a convenient way to produce robust two-mode squeezing and entanglement, which may find potential applications in quantum information processing.
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http://dx.doi.org/10.1364/OE.390647 | DOI Listing |
Sci Adv
January 2025
Institute of Materials Research and Engineering (IMRE), Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Republic of Singapore.
Combining physics with computational models is increasingly recognized for enhancing the performance and energy efficiency in neural networks. Physical reservoir computing uses material dynamics of physical substrates for temporal data processing. Despite the ease of training, building an efficient reservoir remains challenging.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, China.
Although cytotoxic T lymphocytes (CTLs) activation combined with programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis blockade have emerged as an effective strategy to improve immunotherapeutic potency, it remains challenging to realize the spatiotemporal synergy of these two components. Herein, the study reports an engineered bacterial-based delivery system that can simultaneously promote CTLs infiltration and control PD-L1 binding protein (PD-L1 trap) release on demand at tumor site. The drug release button of this tumor targeting system is the specific temperature, which is accomplished by dual-modified melanin nanoparticles with photothermal conversion capacity on the engineered bacterial.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
Department of Textiles, Faculty of Natural Sciences and Engineering, University of Ljubljana, Aškerčeva 12, 1000 Ljubljana, Slovenia.
A smart viscose fabric with temperature and pH responsiveness and proactive antibacterial and UV protection was developed. PNCS (poly-(N-isopropylakrylamide)/chitosan) hydrogel was used as the carrier of silver nanoparticles (Ag NPs), synthesised in an environmentally friendly manner using AgNO and a sumac leaf extract. PNCS hydrogel and Ag NPs were applied to the viscose fabric by either in situ synthesis of Ag NPs on the surface of viscose fibres previously modified with PNCS hydrogel, or by the direct immobilisation of Ag NPs by the dehydration/hydration of the PNCS hydrogel with the nanodispersion of Ag NPs in the sumac leaf extract and subsequent application to the viscose fibres.
View Article and Find Full Text PDFSmall
January 2025
Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230601, P. R. China.
Topical transdermal drug delivery for psoriasis remains a challenge because of the poor solubility of hydrophobic drugs and the limited penetration of the stratum corneum. In this study, a near-infrared (NIR) light-responsive thermosensitive hydrogel (PDLLA-PEG-PDLLA, PLEL)-based drug reservoir is developed that directly incorporated gold nanorods (GNRs) and methotrexate (MTX) in the sol state at low temperature, which is referred to as PLEL@GNR+MTX. The in vitro anti-psoriasis experiment indicated that, GNRs, as photothermal cores of composite hydrogel, not only triggered keratinocyte apoptosis but also promoted MTX release in a synergistic manner.
View Article and Find Full Text PDFNPJ Biofilms Microbiomes
January 2025
Department of Biomedical Engineering, University of Massachusetts Lowell, Lowell, 01854, MA, USA.
The human body houses many distinct and interconnecting microbial populations with long-lasting systemic effects, where the oral cavity serves as a pathogens' reservoir. The correlation of different disease states strongly supports the need to understand the interplay between the oral tissue niche and microbiome. Despite efforts, the recapitulation of gingival architecture and physiological characteristics of the periodontal niche has yet to be accomplished by traditional cultural strategies.
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