AI Article Synopsis
- The study examined the incidence of gestational diabetes mellitus (GDM) in women with twin pregnancies who were treated with vaginal progesterone.
- 203 women received 200 mg of vaginal progesterone daily, while a control group of 1483 women did not.
- Results showed that progesterone treatment did not significantly affect the risk of developing GDM; however, higher pre-pregnancy BMI, previous GDM, and smoking during pregnancy were identified as risk factors.
Article Abstract
Background: In this study, we aimed to investigate the incidence of gestational diabetes mellitus (GDM) in women who carried twin pregnancies and received vaginal progesterone.
Methods: In this retrospective cohort study, 203 out of 1686 women with twin pregnancies received natural progesterone (200 mg/day between gestational weeks 16 + 0 and 36 + 0) vaginally for ≥ 4 weeks. The control group consisted of 1483 women with twin pregnancies without progesterone administration. Pearson's Chi squared test, Fisher's exact test, and Student's t-test was used to compare differences between the control and the progesterone-treated groups. A multivariate binary logistic regression was performed to assess relative independent associations on the dependent outcome of GDM incidence.
Results: Vaginal progesterone treatment in twin pregnancies had no significant influence on developing GDM ( = 0.662). Higher pre-pregnancy BMI (OR 1.1; < 0.001), GDM in previous pregnancy (OR 6.0; < 0.001), and smoking during pregnancy (OR 1.6; = 0.014) posed an increased risk for developing GDM.
Conclusion: In twin pregnancies, the use of vaginal progesterone for the prevention of recurrent preterm delivery was not associated with an increased risk of GDM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408737 | PMC |
| http://dx.doi.org/10.3390/jcm9072249 | DOI Listing |
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