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The endocannabinoid system's genetic polymorphisms in sickle cell anemia patients.
Sci Rep
December 2024
Molecular Biology and Genetics Laboratory (LGBM), UFMS - Federal University of Mato Grosso do Sul, Três Lagoas, Brazil.
Sickle cell anemia (SCA) is a monogenic blood disease with complex and multifactorial pathophysiology. The endocannabinoid system (ECS) could be a candidate for modulating SCA complications, such as priapism, as it has demonstrated an essential role in hematopoiesis, platelet aggregation, and immune responses. We evaluated the association of ECS-related single nucleotide polymorphisms (SNP) (FAAH rs324420, MAGL rs604300, CNR1 rs7766029, and CNR2 rs35761398) with priapism in a Brazilian SCA cohort.
View Article and Find Full Text PDFA contemporary review of the management strategies for sickle cell disease related ischaemic and stuttering priapism.
Int J Impot Res
December 2024
Department of Urology, Guy's & St Thomas' Hospital, London, UK.
Sickle cell disease is one of the most common autosomal recessive genetic disorders with 23% and over 70% of men with this condition, experiencing episodes of ischaemic priapism and stuttering priapism, respectively, with potentially severe consequences. The effective prevention of sickle cell disease induced ischaemic priapism and stuttering priapism requires a multidisciplinary and multimodal approach. A search of the English literature was performed utilising Pubmed® and Google Scholar to identify publications on contemporary and novel treatment options, with their associated treatment outcomes if available, that are utilised to prevent stuttering priapism episodes and hence a fulminant ischaemic priapism.
View Article and Find Full Text PDFNew findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation.
BJU Int
December 2024
Department of Urology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Article Synopsis
- The study aimed to analyze pre- and intraoperative factors influencing the integrity of corporal bodies after placing an inflatable penile prosthesis (IPP), focusing on the occurrence of intraoperative and postoperative complications.
- Researchers reviewed a database of over 5,400 IPP surgeries conducted between 2016 and 2021, identifying significant predictors for complications linked to corporal integrity.
- Key predictors for complications included revision surgery, older age, and medical conditions like coronary artery disease or peripheral vascular disease, indicating the need for consideration of these factors during IPP placement to reduce risks.
The assessment and aetiology of drug-induced ischaemic priapism.
Int J Impot Res
December 2024
Associate Professor in the Division of Urology, Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ischaemic priapism is a urological emergency characterised by a prolonged, painful erection unrelated to sexual stimulation. While several aetiological factors contribute to this condition, the pharmacological causes have gained significant attention in recent years. This narrative review aims to comprehensively assess ischaemic priapism, specifically focusing on its pharmacological aetiology.
View Article and Find Full Text PDFIdiopathic recurrent ischemic priapism: a review of current literature and an algorithmic approach to evaluation and management.
Basic Clin Androl
December 2024
NOVO Hospital, Paris, Pontoise, France.
Background: Stuttering priapism is characterized by recurrent, self-limited episodes of penile erection lasting from a few minutes to a maximum of three hours, often resolving spontaneously. These episodes can occur with or without sexual stimulation. If not treated promptly and effectively, stuttering priapism can severely impact a patient's quality of life, leading to significant psychological distress and anxiety related to sexual performance.
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