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[Clinical Outcomes of Transurethral Water Vapor Energy Therapy with Rezumᵀᴹ System].
Hinyokika Kiyo
November 2024
The Department of Urology, Kitasato University School of Medicine.
We carefully reviewed and evaluated the efficacy of transurethral water vapor energy therapy (WAVE) with Rezumᵀᴹ system for treatment of benign prostatic hyperplasia. Between April and September 2023, 41 patients received WAVE under local anesthesia as day surgery at the outpatient department in our institution. The mean age as of operation was 78.
View Article and Find Full Text PDF[A preliminary study on the short-term effectiveness and safety of sublingual immunotherapy-spray for patients with respiratory allergy].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing210029, China International Centre for Allergy Research, Nanjing Medical University, Nanjing210029, China.
To investigate the short-term effectiveness and safety of sublingual allergen immunotherapy with allergen sprays (SLIT-sprays) in Chinese patients with allergic rhinitis (AR) with or without asthma using real-world data. The retrospective cohort study included 100 patients who received SLIT-sprays in the ENT departments in Hainan Shulan (Boao) Hospital and Boao Super Hospital between October 2023 and August 2024. A questionnaire survey was conducted to collect clinical data on the effectiveness and safety of SLIT-sprays, examining the types and incidence of adverse events (AEs) during treatment, treatments after the occurrence of AEs, and changes in Visual Analog Scale (VAS) scores before and after SLIT-sprays.
View Article and Find Full Text PDF[Expert consensus on autoantibody detection and application in primary healthcare institutions].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Autoantibody detection is important in the diagnosis, classification, condition assessment and therapeutical effect monitoring of autoimmune disease. To improve the diagnosis and treatment ability of autoimmune disease in primary healthcare institutions in China, Grassroots Inspection Technology Standardization Branch of China International Exchange and Promotive Association for Medical and Health Care organized experts from various clinical specialties, such as the department of laboratory medicine and the department of rheumatology, to publish the "Expert consensus on autoantibody detection and application in primary healthcare institutions", so as to promote the professionalization and standardization of autoantibody detection and application in primary healthcare institutions.
View Article and Find Full Text PDF[Analysis of hospitalization status by major classification according to ICD-10 among public assistance recipients considering sex and age].
Nihon Koshu Eisei Zasshi
December 2024
Department of Public Health, Kurume University School of Medicine.
Objectives We evaluated the number of hospitalizations among public assistance recipients for each major classification according to the International Classification of Diseases 10th Revision (ICD-10), adjusting for sex and age differences in the general Japanese population. This study aimed to provide a comprehensive assessment of hospitalization patterns among public assistance recipients by disease category.Methods We used indirect methods to adjust for sex and age, with public assistance recipients and the entire Japanese population as the observation and reference groups, respectively.
View Article and Find Full Text PDF[Donor DNA Modification with Cas9 Targeting Sites Improves the Efficiency of MTC34 Knock-in into the CXCR4 Locus].
Mol Biol (Mosk)
December 2024
Center of Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.
To successfully apply the genome editing technology using the CRISPR/Cas9 system in the clinic, it is necessary to achieve a high efficiency of knock-in, which is insertion of a genetic construct into a given locus of the target cell genome. One of the approaches to increase the efficiency of knock-in is to modify donor DNA with the same Cas9 targeting sites (CTS) that are used to induce double-strand breaks (DSBs) in the cell genome (the double-cut donor method). Another approach is based on introducing truncated CTS (tCTS), including a PAM site and 16 proximal nucleotides, into the donor DNA.
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