AI Article Synopsis
- Lung adenocarcinomas have varying prognoses based on their growth patterns, with adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) showing the best outcomes when surgically removed.
- Solid and micropapillary-predominant types have worse prognoses, while other patterns are intermediate.
- Recent findings emphasize the significance of specific histologic features, like complex acinar formations, which are essential for prognosis and have become important since the World Health Organization updated its classification guidelines.
Article Abstract
Lung adenocarcinomas differ in prognosis based on their histologic growth pattern. Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) both have an excellent prognosis when completely resected, whereas solid and micropapillary-predominant adenocarcinomas do not, with other patterns falling in between. In recent years, it has become apparent that even within histologic patterns, there are differences in appearance that are clinically important, such as complex acinar formations and highly variable-sized papillae. This review highlights prognostically important histologic features in lung adenocarcinoma that have emerged since implementation of the current World Health Organization (WHO) classification of lung adenocarcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354137 | PMC |
| http://dx.doi.org/10.21037/tlcr.2019.12.30 | DOI Listing |
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