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Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1.
J Clin Invest
December 2024
Department of Stomatology, Union Hospital and.
Article Synopsis
- Aging is linked to changes in circadian rhythms and stem cell depletion, but the influence of circadian systems on skeletal aging is not fully understood.
- In male mice, reduced levels of the circadian protein BMAL1 in bone marrow endothelial cells were found to disrupt the balance of extracellular matrix proteins, leading to increased breakdown of fibrillin-1 (FBN1) which affects bone health.
- The loss of BMAL1 activates TGF-β signaling, promoting further breakdown of FBN1 and resulting in stem cell exhaustion and increased osteoclast activity, highlighting the role of endothelial cells in maintaining skeletal integrity during aging.
Thyroid response to blocking sympathetic activity in chronic cold exposed hunters in East Greenland: a case-control study.
Eur Thyroid J
December 2024
S Andersen, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Background: Thyroid hormones and sympathetic stimulation are needed for activating Brown adipose tissue (BAT) during cold exposure. Studies of human cold exposure have demonstrated both increased production and raised clearance of triiodothyronine (T3). Greenlandic hunters provide a unique model for evaluating metabolic effects of cold exposure.
View Article and Find Full Text PDFPosition Paper of the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) and the German Roentgen Society (DRG) on Structural and Professional Requirements in Interventional Oncology.
Rofo
November 2024
Institute for Diagnostic and Interventional Radiology, HELIOS Hospital Krefeld, Krefeld, Germany.
Interventional oncology (IO) employs various techniques to enable minimally invasive, image-guided treatment of tumor diseases with both curative and palliative goals. Additionally, it significantly contributes to managing tumor-related and perioperative complications, offering diverse supportive procedures for patients at all stages of their diseases. The execution of IO procedures places unique demands on the equipment, personnel, and structural organization of radiological clinics, necessitating specific expertise from interventional radiologists.
View Article and Find Full Text PDFDioscin improves fatty liver hemorrhagic syndrome by promoting ERα-AMPK mediated mitophagy in laying hens.
Phytomedicine
December 2024
Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
Article Synopsis
- Mitochondria are important for energy balance in the body, and their damage is linked to a condition called fatty liver hemorrhagic syndrome (FLHS) in chickens.
- Dioscin is a natural substance that can help fix problems in damaged mitochondria, but its specific effects on FLHS were not well known.
- The research found that dioscin can protect laying hens from FLHS by reducing damage to their liver cells and improving how their body processes fat, showing that it works by activating certain signaling pathways.
Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNA.
J Cell Sci
October 2024
Laboratory of Biomechanics, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara, Sakyo, Kyoto 606-8507, Japan.
In eukaryotic cell nuclei, specific sets of proteins gather in nuclear bodies and facilitate distinct genomic processes. The nucleolus, a nuclear body, functions as a factory for ribosome biogenesis by accumulating constitutive proteins, such as RNA polymerase I and nucleophosmin 1 (NPM1). Although in vitro assays have suggested the importance of liquid-liquid phase separation (LLPS) of constitutive proteins in nucleolar formation, how the nucleolus is structurally maintained with the intranuclear architecture remains unknown.
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