Hypothesis: Production of corrugated particles generally introduces several morphological heterogeneities, such as surface roughness and local variations in the corrugation pattern, which are known from model system studies to significantly alter the colloidal interaction energy. Thus, realistic particle morphologies need to be investigated and compared to simple model shapes to yield insights into how interactions are influenced by such morphological heterogeneities.
Experiments: We applied the surface element integration method to study the colloidal interactions of electron tomography-based, realistic, corrugated colloidal particles and their symmetric, concave polyhedral analogs by differentiating local surface features to vertices, ridges and ridge networks. We applied molecular modelling to assess the surface access of these features.
Findings: Significant mixing of the interaction energy was found between the different surface features. Larger and smaller energy barrier heights and secondary minimum depths were observed compared to the concave polyhedral models with similar volume or surface area depending on the contacting surface feature. Analysis of surface area distributions suggests that the deviations originate from the altered effective contact distance as a result of surface roughness and other morphological heterogeneities. We also found that the surface access of nanoparticles is greatly impaired at the crevices between the surface corrugations.
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http://dx.doi.org/10.1016/j.jcis.2020.06.082 | DOI Listing |
Clinics (Sao Paulo)
January 2025
Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Anhui Province, China. Electronic address:
Objective: TRIB3 has been confirmed to participate in and regulate biological metabolic activities in head and neck tumors such as nasopharyngeal carcinoma and oropharyngeal carcinoma, so the purpose of this study was to explore whether there is a correlation between TRIB3 and Laryngeal Squamous Cell Carcinoma (LSCC) and to preliminarily explore the biological characteristics of TRIB3 in LSCC.
Methods: TRIB3 expression in the LSCC was analyzed based on The Cancer Genome Atlas (TCGA) database. CCK-8 assay, Colony Formation Assay, wound healing assay, and Transwell assay were performed to investigate the roles of TRIB3 in the proliferation, invasion and metastasis of LSCC.
Biomed Phys Eng Express
January 2025
Children's Hospital of Eastern Switzerland, Claudiusstrasse 6, St.Gallen, 9006, SWITZERLAND.
Mapping the myomagnetic field of a straight and easily accessible muscle after electrical stimulation using triaxial optically pumped magnetometers (OPMs) to assess potential benefits for magnetomyography (MMG). Approach: Six triaxial OPMs were arranged in two rows with three sensors each along the abductor digiti minimi (ADM) muscle. The upper row of sensors was inclined by 45° with respect to the lower row and all sensors were aligned closely to the skin surface without direct contact.
View Article and Find Full Text PDFJ Radiol Prot
January 2025
Department of Mechanical Engineering, University of Houston, Houston, 77204, UNITED STATES.
Although the Boundary Representation (BREP) method creates detailed surface phantoms of Chinese women of childbearing age, these phantoms cannot be directly used in Monte Carlo simulations. They must first be converted into voxel phantoms, a process that may diminish some of the inherent advantages of the surface phantoms. Therefore, the aim of this study is to construct a tetrahedral mesh (TM) phantom of Chinese women of childbearing age based on the BREP phantom, incorporating micron-level structural refinements to certain organ tissues while maintaining the original model's structure.
View Article and Find Full Text PDFAnal Chem
January 2025
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Ligand binding to membrane proteins initiates numerous therapeutic processes. Surface plasmon resonance (SPR), a popular method for analyzing molecular interactions, has emerged as a promising tool for in situ determination of membrane protein binding kinetics owing to its label-free detection, high surface sensitivity, and resistance to intracellular interference. However, the excitation of SPR relies on noble metal films, typically gold, which are biologically incompatible and can cause fluorescence quenching.
View Article and Find Full Text PDFBlood
January 2025
New York Blood Center, New York, New York, United States.
Babesiosis in sickle cell disease (SCD) is marked by severe anemia but the underlying red blood cell (RBC) rheological parameters remain largely undefined. Here, we describe altered RBC deformability from both primary (host RBC sickle hemoglobin mediated) and secondary changes (Babesia parasite infection mediated) to the RBC membrane using wild type AA, sickle trait AS and sickle SS RBCs. Our ektacytometry (LORRCA) analysis demonstrates that the changes in the host RBC bio-mechanical properties, pre- and post- Babesia infection, reside on a spectrum of severity, with wild type infected AA cells, despite showing a significant reduction of deformability under both shear and osmolarity gradients, exhibiting only a mild phenotype; compared to infected AS RBCs which show median changes in deformability and infected SS RBCs which exhibit the most dramatic impact of infection on cellular rheology, including an increase in Point of Sickling values.
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