Usability is a quality attribute that can evaluate the ease of use of user interfaces, based on standards called usability heuristics. To evaluate the usability components of the Brazilian Immunization Information System (IIS), focusing on the users and their interaction and agility with the interfaces. It was a concomitant and convergent mixed-method study that used a cross-sectional design for the quantitative approach and the indirect method of heuristic evaluation for the qualitative approach. Participants were 137 nursing professionals working in vaccination rooms, who completed a structured questionnaire on standards of usability quality, and 4 specialists in information technology, who used a semistructured form to carry out a software inspection. Descriptive and inferential statistics and the heuristic inspection were used for the analyses. The evaluation resulted in 10 violated heuristics and identified 14 usability problems on the 68 screens of the IIS. The system presented simple usability problems (grade 2 severity), which can be repaired, with a low correction priority. The heuristics best evaluated were error prevention (3.03 ± 0.54) and help and documentation (3.00 ± 0.68); and the worst evaluated was visibility of system status, with a mean of 2.62 ± 0.55. Professionals with a technical education level presented a higher score on the scales for the recognition rather than recall heuristic when compared with the nurses (2.77 ± 0.49 vs. 3.67 ± 0.66, p = 0.003). The system provides easy access for users, however, has weaknesses in its ability to allow the users to easily achieve their goals of interaction with the interface.
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http://dx.doi.org/10.1089/tmj.2020.0077 | DOI Listing |
Curr Cardiol Rep
January 2025
Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8086, St. Louis, MO, 63110, USA.
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Sleep Breath
January 2025
Department of Respiratory and Critical Care Medicine, Medical School of Nantong University, Nantong Key Laboratory of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
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January 2025
Model System for Infection and Immunity, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
Two features of macrophages make them attractive for targeted transport of drugs: they efficiently take up a broad spectrum of nanoparticles (NPs) and, by sensing cytokine gradients, they are attracted to the sites of infection and inflammation. To expand the potential of macrophages as drug carriers, we investigated whether macrophages could be simultaneously coloaded with different types of nanoparticles, thus equipping individual cells with different functionalities. We used superparamagnetic iron oxide NPs (SPIONs), which produce apoptosis-inducing hyperthermia when exposed to an alternating magnetic field (AMF), and co-loaded them on macrophages together with drug-containing NPs (inorganic-organic nanoparticles (IOH-NPs) or mesoporous silica NPs (MSNs)).
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Unlabelled: Group A (GAS) is a major human pathogen that causes several invasive diseases including necrotizing fasciitis. The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tissues. GAS, especially skin-tropic bacterial strains, utilize specific virulence factors, plasminogen binding M-protein (PAM) and streptokinase (SK), to manipulate hemostasis and activate plasminogen to cause fibrinolysis and fibrin clot escape.
View Article and Find Full Text PDFCardiovasc Res
January 2025
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Aims: The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active endocrine organ. Microbes produce metabolites, which can be taken up by the host and can actively communicate with the immune cells in the gut lamina propria with consequences for cardiovascular health.
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