By doping a laser dye into two polyurethane layers in a guided-mode resonance (GMR) structure, we observed that the lasing emission can be enhanced by approximately fivefold. The structure comprises, from top to bottom, a grating layer, four alternating layers of polyurethane and , and a bottom substrate. Two different GMR wavelengths can be generated because of the two films of serving as waveguide layers. The enhancement of the lasing emission is achieved by matching both the absorption and emission wavelength of the laser dye with the two GMR wavelengths. When the absorption wavelength matches the GMR wavelength, the formation of high intensity near the polyurethane layer serves to efficiently excite the laser dye. Additionally, as the emission wavelength overlaps with the GMR wavelength, the extraction of lasing intensity can be further increased in the preferred directions owing to the high reflection efficiency and directivity of the GMR. Moreover, we found that the linewidth is reduced to approximately 1.06 nm, and the estimated threshold is approximately 0.92/ when both excitation and extraction resonances occur in the waveguide structure.
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http://dx.doi.org/10.1364/AO.396729 | DOI Listing |
Photodiagnosis Photodyn Ther
January 2025
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:
Background: Candida albicans is the primary cause of vulvovaginal candidiasis, a worldwide health concern for women. The use of supplemental methods, such as antimicrobial photodynamic therapy (aPDT) and probiotics, was promoted by the ineffectiveness of the existing antifungal drugs.
Methods: This study examines the combined effects of probiotics (Bacillus and Enterococcus isolated from the fermented pickles) and PDT (using red laser (655 nm, 18 J/cm) as a light source and methylene blue dye (30 mg/mL) as a photosensitizer) on the in vitro virulence activity of C.
ACS Appl Mater Interfaces
January 2025
Sixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
The use of dual-tracer contrast agents in clinical applications, such as sentinel lymph node (SLN) identification, offers significant advantages including enhanced accuracy, sensitivity, as well as comprehensive and multimodal visualization. In the current clinical practice, SLNs are typically marked prior to surgical resection by multiple and sequential injections of two tracers, the radioactive tracer and methylene blue (MB) dye. This imposes physical and psychological burden on patients and medical staff.
View Article and Find Full Text PDFSci Rep
January 2025
Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa.
The simultaneous administration of multiple drugs within identical nanocarriers to cancer cells or tissues can result in the effective action of drugs at reduced concentrations. In this investigation, PAMAM dendrimers (G4-PAMAM) were employed to link with methotrexate (MTX) using DCC/NHS chemistry and followed by the entrapment of curcumin (Cur) within it. The establishment of covalent bonds between MTX and the PAMAM dendrimer led to PAMAM-MTX interaction, verified and described through FT-IR.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Biology, University at Albany, SUNY, 1400 Washington Ave, Albany, NY 12222, United States.
The accuracy of assigning fluorophore identity and abundance, known as spectral unmixing, in biological fluorescence microscopy images remains a significant challenge due to the substantial overlap in emission spectra among fluorophores. In traditional laser scanning confocal spectral microscopy, fluorophore information is acquired by recording emission spectra with a single combination of discrete excitation wavelengths. However, organic fluorophores possess characteristic excitation spectra in addition to their unique emission spectral signatures.
View Article and Find Full Text PDFJ Lasers Med Sci
November 2024
Department of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Trastuzumab is now increasingly being used as a potent HER2 inhibitor in treating breast cancer, while acneiform rashes sometimes arise as skin-related side effects in patients undergoing treatment with HER2 inhibitors, and their specificity as drug-induced eruptions makes their management quite challenging. Pulsed dye laser (PDL) therapy has been utilized to treat a wide variety of vascular lesions, achieving excellent outcomes. A 595 nm PDL was used to treat a 38-year-old woman suffering from an acneiform rash induced by trastuzumab as neoadjuvant therapy for breast cancer.
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