AI Article Synopsis
Article Abstract
The metabolism of bifenthrin (BIF), β-cyfluthrin (CYFL), λ-cyhalothrin (CYHA), cyphenothrin (CYPH) and esfenvalerate (ESF) was studied in liver microsomes, liver cytosol and plasma from male Sprague-Dawley rats aged 90, 21 and 15 days and from adult humans. Pyrethroid metabolism was also studied with some human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. All five pyrethroids were metabolised by adult (90 day old) rat hepatic microsomal CYP and CES enzymes and by cytosolic CES enzymes. The pyrethroids were also metabolised by human liver microsomes and cytosol. Some species differences were observed. Pyrethroid metabolism by cytosolic CES enzymes contributes to the overall hepatic clearance of these compounds. CYFL, CYHA, CYPH and ESF were metabolised by rat plasma CES enzymes, whereas none of the pyrethroids were metabolised by human plasma. This study demonstrates that the ability of male rats to metabolise these pyrethroids by hepatic CYP and CES enzymes and plasma CES enzymes increases with age. In all instances, apparent intrinsic clearance values were lower in 15 than in 90 day old rats. All pyrethroids were metabolised by some of the human expressed CYP enzymes studied and apart from BIF were also metabolised by CES enzymes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/00498254.2020.1795745 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seroprevalence and risk factors of brucellosis in pastoralists and their livestock in Central Equatoria State, South Sudan.
PLoS Negl Trop Dis
December 2024
Department of Veterinary Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.
Background: Brucellosis poses serious public health implications and substantial economic losses in pastoral rural settings in South Sudan. In humans, brucellosis is almost always originating from animals. Current literature provides scant data regarding the seroprevalence of brucellosis in South Sudan.
View Article and Find Full Text PDFConjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease.
Arch Pharm (Weinheim)
January 2025
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.
New conjugates of amiridine and salicylic derivatives (salicylamide, salicylimine, and salicylamine) with different lengths of alkylene spacers were designed, synthesized, and evaluated as potential multifunctional central nervous system therapeutic agents for Alzheimer's disease (AD). Conjugates demonstrated high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition (IC: AChE, 0.265-4.
View Article and Find Full Text PDFDiversity and functional role of bacterial microbiota in spontaneous coffee fermentation in northern Peru using shotgun metagenomics.
J Food Sci
December 2024
Instituto de Investigación para el Desarrollo Sustentable de Ceja de Selva (INDES-CES), Universidad Nacional Toribio Rodríguez de Mendoza, Chachapoyas, Amazonas, Peru.
Article Synopsis
- Peru is a significant player in the coffee market, ranking as the ninth-largest producer and the leading exporter of organic coffee globally, with a focus on how fermentation affects flavor.
- This study explored the diversity of bacterial communities during different fermentation durations in northern Peru using advanced genetic sequencing techniques, highlighting the critical role of specific acid-tolerant bacteria in enhancing coffee quality.
- Results showed that longer fermentation periods positively influence the sensory attributes of coffee by promoting the production of various enzymes and volatile compounds, suggesting that these processes could lead to higher-quality beans and offer new biotechnological opportunities.
Assessment of hypolipidemic potential of cholesteryl esterase inhibitory peptides in different probiotic fermented milk through in vitro, , and molecular docking studies.
Food Chem X
December 2024
Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
Fermented milk (FM) is well-known to confer health-promoting benefits, particularly for managing chronic metabolic diseases. However, the specific cholesterol esterase (CE) inhibitory activities of FM produced from different animal milk sources have not been extensively explored. This study for the first time investigates the CE inhibition potential of FM derived from bovine (F_BM), camel (F_CM), sheep (F_SM), and goat milk (F_GM), each fermented with five different probiotic strains and stored for 14 days under refrigeration.
View Article and Find Full Text PDFRegulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins.
Trends Cell Biol
November 2024
Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Article Synopsis
- The superfamily of hydroxysteroid dehydrogenases (HSDs) includes enzymes crucial for lipid and steroid hormone metabolism across various organisms.
- Recent studies have identified a subset of these enzymes, like 3β-HSD, 11β-HSD, and 17β-HSD, as proteins associated with lipid droplets (LDs) that play roles in LD dynamics beyond their typical functions.
- The review explored these LD-associated HSDs, detailing their regulation of different neutral lipids, the preservation of lipids by 17β-HSDs, and the potential for targeting these enzymes in treating metabolic diseases and viral infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!