AI Article Synopsis
- Head and neck neoplasms often have a poor prognosis due to late diagnosis, making early detection crucial for improving survival rates.
- This literature review discusses various biomarker research efforts across different -omics fields aimed at early diagnosis of these tumors.
- Currently, no effective biomarkers or panels have been identified for clinical use, largely due to issues like study group diversity and inadequate sensitivity or specificity, highlighting the need for further research.
Article Abstract
Head and neck neoplasms have a poor prognosis because of their late diagnosis. Finding a biomarker to detect these tumors in an early phase could improve the prognosis and survival rate. This literature review provides an overview of biomarkers, covering the different -omics fields to diagnose head and neck neoplasms in the early phase. To date, not a single biomarker, nor a panel of biomarkers for the detection of head and neck tumors has been detected with clinical applicability. Limitations for the clinical implementation of the investigated biomarkers are mainly the heterogeneity of the study groups (e.g., small population in which the biomarker was tested, and/or only including high-risk populations) and a low sensitivity and/or specificity of the biomarkers under study. Further research on biomarkers to diagnose head and neck neoplasms in an early stage, is therefore needed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332560 | PMC |
| http://dx.doi.org/10.3389/fonc.2020.01020 | DOI Listing |
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