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The experiments were undertaken to determine the effect of Peroxinorm (superoxide dismutase) on the activity of interleukin-1 in vitro. The results give evidence that the influence of the drug examined on the activity/production of interleukin-1 can take different forms, relative to the concentration applied. At higher dilution (10(-7)) Peroxinorm suppressed the activity of Il-1, whereas at lower dilutions it was devoid of this effect. A conceivable mechanism of its activity in the treatment of the inflammations is also discussed.
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