The mirror neuron system has been argued to be a key brain system responsible for understanding the actions of others and for imitation. It has therefore been proposed that problems within this system could explain the social difficulties experienced by people with autism spectrum condition. This idea is referred to as the broken mirror hypothesis. However, research has produced insufficient evidence to support the broken mirror hypothesis in its original form. Therefore, two other models have been suggested: EP-M model and the social top-down response modulation (STORM) model. All models suggest something is different regarding the mirror neuron system in autism spectrum condition: either within the mirror neuron system itself or within the systems that control the activity of the mirror neuron system. This literature review compares these three models in regard to recent neuroscientific investigations. This review concludes that there is insufficient support for both the broken mirror hypothesis, but converging evidence supports an integrated EP-M and STORM model.
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http://dx.doi.org/10.1177/1362361320936945 | DOI Listing |
Lung Cancer (Auckl)
December 2024
University of California Irvine School of Medicine, Department of Medicine, Orange, CA, 92868, USA.
Mutations in KRAS G12C are among the more common oncogenic driver mutations in non-small cell lung cancer (NSCLC). In December 2022, the US Food and Drug Administration (FDA) granted accelerated approval to adagrasib, a small molecule covalent inhibitor of KRAS G12C, for the treatment of patients with locally advanced or metastatic KRAS G12C mutant NSCLC who received at least one prior systemic therapy based on promising results from phase 1 and 2 trials wherein adagrasib demonstrated a median PFS of 6.5 months.
View Article and Find Full Text PDFPhys Rev E
November 2024
Landau Institute for Theoretical Physics, Russian Academy of Sciences, 1-A Akademika Semenova av., 142432 Chernogolovka, Russia and National Research University Higher School of Economics, Faculty of Physics, Myasnitskaya 20, 101000 Moscow, Russia.
We study one-point statistics of helical turbulent pulsations in the background of a three-dimensional large-scale vortex in a rotating fluid. Assuming that the helical flow is created by a statistically axially symmetric random force with broken mirror symmetry, we analytically calculate the velocity-vorticity mean including its magnitude and the anisotropy. For electrically conducting liquid, we examine the α-effect in the system.
View Article and Find Full Text PDFCureus
November 2024
Dermatopathology, Regional Medical Laboratory and Pathology Laboratory Associates, Tulsa, USA.
We present a rare case of rhabdoid squamous cell carcinoma (RSCC) on the scalp of a non-immunosuppressed male patient in his late 60s. This aggressive variant of squamous cell carcinoma (SCC) is characterized by tumor cells with eccentrically located nuclei and abundant eosinophilic cytoplasm, as observed on histopathological examination. While rhabdoid morphology has been reported in various anatomical sites, its occurrence in primary cutaneous tumors is exceptionally uncommon, with fewer than 10 cases documented to date.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
Nonlinear Physics Center, Research School of Physics, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
We demonstrate that chiral response can be achieved in resonant metasurfaces with a monoclinic lattice symmetry (the so-called Bravais oblique lattices) where the mirror symmetry is broken by the lattice asymmetry and also by a substrate, whereas each individual meta-atom remains fully achiral. We describe the underlying physics by introducing a mode chirality parameter as a quantitative measure of the lattice chiral eigenmodes. We confirm experimentally selective linear and nonlinear chiral interaction of resonant silicon metasurfaces with circularly polarized light.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Physics, and State Key Laboratory of Silicon Materials and Advanced Semiconductor Materials, Zhejiang University, Hangzhou, 310027, China.
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