New Copper(I) Complex with a Coumarin as Ligand with Antibacterial Activity against .

Molecules

Laboratory of Natural Products Chemistry, Centre of Aquatic Biotechnology, Faculty of Chemistry and Biology, University of Santiago of Chile, 9170002 Santiago, Chile.

Published: July 2020

A new copper (I) complex, [Cu(NN)](ClO) was synthesized, where NN was a imine ligand 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one obtained by a derivatization of natural compound coumarin. The structural characterization in solution was done by NMR techniques, UV-Vis and cyclic voltammetry. The potential antibacterial effect of [Cu(NN)](ClO) was assessed for isolated 10094. is a Gram-negative bacterium which causes diseases such as bacterial cold-water disease and rainbow trout fry syndrome, causing large economic losses in the freshwater salmonid aquaculture industry. This complex show to have antibacterial activity against 10094 at non-cytotoxic concentration in cell line derived from trout ( 10094 IC 16.0 ± 0.9; RT-GUT IC 53.0 ± 3.1 µg/mL).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397040PMC
http://dx.doi.org/10.3390/molecules25143183DOI Listing

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