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Keratinocyte-Polyamines and Dendritic Cells: A Bad Duet for Psoriasis. | LitMetric
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Keratinocyte-Polyamines and Dendritic Cells: A Bad Duet for Psoriasis.

Mohna Bandyopadhyay Adriana T Larregina

Immunity

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; McGowan Center for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

Published: July 2020

The role of keratinocyte metabolism in psoriasis is not fully elucidated. In this issue of Immunity, Lou et al. describe that interleukin-17 (IL-17) re-programs the urea cycle in keratinocytes increasing polyamines that stabilize RNA-Ag-complexes that upon cellular turnover activate dendritic cells, which amplify psoriasis inflammation.

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http://dx.doi.org/10.1016/j.immuni.2020.06.015DOI Listing

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