Oncogenes Feed Treg Cells without Calling CD8s to the Table.

Immunity

Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. Electronic address:

Published: July 2020

Metabolic support for regulatory T (Treg) cells in noninflamed tumors is not well understood. In this issue of Immunity, Kumagai et. al. show how oncogene-driven fatty-acid synthesis favors Treg cells over effector T cells and how this imbalance can be overcome.

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Source
http://dx.doi.org/10.1016/j.immuni.2020.06.020DOI Listing

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