AI Article Synopsis
- The study investigates if patients sensitized to methylisothiazolinone (MI) also react to other isothiazolinone derivatives, specifically octylisothiazolinone (OIT) and benzisothiazolinone (BIT).
- Out of 116 patients tested, 13% were sensitized to MI, with a subset showing positive reactions to OIT upon re-testing.
- The findings suggest that strong sensitization to MI may lead to immunologic cross-reactivity with OIT, but less so with BIT.
Article Abstract
Background: Notwithstanding that concomitant exposure to different isothiazolinone derivatives may result in concomitant sensitization, clinical and animal studies have suggested cross-reactivity between these derivatives, notably between methylisothiazolinone (MI) and octylisothiazolinone (OIT).
Objective: To investigate if patients sensitized to MI show cross-reactions to OIT and/or to benzisothiazolinone (BIT) by applying the concept of the re-test method.
Patients And Methods: From March to October 2019 consecutive patients were patch tested with MI 0.2% aqueous in duplicate at the two lower corners of both shoulder blades. Patients sensitized to MI, but not to OIT 0.1% petrolatum (pet.) nor to BIT 0.1% pet., were re-tested, 2 months later, with the latter two derivatives at the skin sites where the MI reactions had fully disappeared.
Results: Of 116 patients, 15 (13%) were sensitized to MI, eight of these not sensitized to BIT nor to OIT. Of these, seven patients, all (very) strongly sensitized to MI, were re-tested: five patients showed positive patch test reactions to OIT 0.1% pet.; one patient to OIT 0.1% pet. and BIT 0.1% pet.; and one other patient showed no reactions.
Conclusion: This study suggests that patients primarily and strongly sensitized to MI may show immunologic cross-reactions to OIT, and to a far lesser extent to BIT.
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| http://dx.doi.org/10.1111/cod.13661 | DOI Listing |
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