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SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity. | LitMetric

AI Article Synopsis

  • Initial studies show that serology tests for SARS-CoV-2 can be useful, but more research is needed to understand antibody levels and their effect on immunity and disease progression.
  • In a study of 967 subjects, the tests were able to accurately identify IgG antibodies in most cases after 14 days from symptom onset, with IgM showing positive results early in the infection.
  • The IgG test had great specificity and did not react with other viruses, but both IgG and IgM levels were not linked to the severity of the disease in the participants.

Article Abstract

Objectives: Initial reports indicate adequate performance of some serology-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assays. However, additional studies are required to facilitate interpretation of results, including how antibody levels impact immunity and disease course.

Methods: A total of 967 subjects were tested for IgG antibodies reactive to SARS-CoV-2, including 172 suspected cases of SARS-CoV-2, 656 plasma samples from healthy donors, 49 sera from patients with rheumatic disease, and 90 specimens from individuals positive for polymerase chain reaction (PCR)-based respiratory viral panel. A subgroup of SARS-CoV-2 PCR-positive cases was tested for IgM antibodies by proteome array method.

Results: All specificity and cross-reactivity specimens were negative for SARS-CoV-2 IgG antibodies (0/795, 0%). Positive agreement of IgG with PCR was 83% of samples confirmed to be more than 14 days from symptom onset, with less than 100% sensitivity attributable to a case with severe immunosuppression. Virus-specific IgM was positive in a higher proportion of cases less than 3 days from symptom onset. No association was observed between mild and severe disease course with respect to IgG and IgM levels.

Conclusions: The studied SARS-CoV-2 IgG assay had 100% specificity and no adverse cross-reactivity. Measures of IgG and IgM antibodies did not predict disease severity in our patient population.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454292PMC
http://dx.doi.org/10.1093/ajcp/aqaa123DOI Listing

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