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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. | LitMetric

AI Article Synopsis

  • * CoVex is an online platform that combines virus-human protein interactions, human protein interactions, and drug-target data for research purposes.
  • * The platform allows users to visually explore these interactions and uses network-based predictions to identify potential drug candidates, aiding in COVID-19 drug research.

Article Abstract

Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360763PMC
http://dx.doi.org/10.1038/s41467-020-17189-2DOI Listing

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