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Skin Tape Stripping Reveals Distinct Biomarker Profiles in Chronic Hand Eczema of Patients With and Without Comorbid Atopic Dermatitis.
Allergy
January 2025
Department of Dermatology, Icahn School of Medicine at the Mount Sinai, New York, New York, USA.
Introduction: Chronic hand eczema (CHE) is a highly prevalent inflammatory skin condition which is often resistant to conventional treatments. Molecular insights of CHE remain limited. Tape stripping combined with high-throughput RNA sequencing can now provide a better insight into CHE pathogenesis in a minimally invasive fashion.
View Article and Find Full Text PDFHand Eczema. Part 1: epidemiology, pathogenesis, diagnosis and work-up.
J Am Acad Dermatol
October 2024
Icahn School of Medicine at Mount Sinai School of Medicine, New York, New York.
Hand eczema (HE), also referred to as hand dermatitis, is a frequent medical condition that can have an important negative impact on quality of life. Occupational HE is an important cause of medical disability. Multiple inflammatory pathways are upregulated, and barrier genes are downregulated in HE.
View Article and Find Full Text PDFHand eczema in Italian patients referred for patch testing: A retrospective SIDAPA study (2016-2023).
Contact Dermatitis
January 2025
Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Article Synopsis
- Hand eczema (HE) significantly impacts quality of life and lacks comprehensive data for Italian patients undergoing patch testing, highlighting the need for a better understanding of this condition.
- A study analyzed 1,597 HE patients over seven years, revealing key demographic and clinical information, such as that 60.2% were in the HE-only group and 33.2% of these had occupational dermatitis.
- Results showed common allergic and irritant responses in HE-only patients, with significant patch test reactions primarily to nickel and various preservatives, emphasizing unique traits within this patient population.
Hand eczema: a review of clinical, dermoscopic and histological features.
Ital J Dermatol Venerol
October 2024
Department of Medical Sciences, Clinic of Dermatology, University of Turin, Turin, Italy -
Article Synopsis
- Hand eczema (HE) is a common skin condition affecting 15-20% of people, with women having a higher prevalence; it presents with symptoms like itchy, red, swollen plaques, and blisters.
- A literature search using terms related to HE was conducted across various medical databases to gather and evaluate existing research, guided by the PRISMA algorithm for screening relevant articles up to October 2023.
- HE is often linked with atopic dermatitis and includes subtypes like irritant and allergic contact dermatitis, making it a challenging condition to manage; the paper aims to create a detailed classification system using clinical observations, dermoscopy, and histological data, highlighting its impact on daily life and the workplace.
Background: Acne vulgaris (AV) is the eighth most common nonfatal disease globally. Previous work identified an association between AV and increased filaggrin (FLG) protein expression in the follicular epidermis, but further work did not find a clear link between loss-of-function (LoF) FLG gene mutations and protection from AV.
Objectives: To explore any association between AV and FLG LoF mutations in a cohort of genotyped patients of Bangladeshi ancestry with atopic eczema (AE) in East London.
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