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Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels.
Medicina (Kaunas)
January 2025
Department of Neurology and Neurosurgery, Riga East University Hospital, LV-1038 Riga, Latvia.
Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient's daily activities. The aim of our study was to investigate the correlation between functional status, cognitive functions, and neurofilament light chain levels in plasma in MS patients.
View Article and Find Full Text PDFValidation of the Italian Sense of Agency Scale and Its Relevance to Well-Being: An Iterative Bootstrap Approach.
Behav Sci (Basel)
December 2024
Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
The Sense of Agency (SoA) refers to the subjective experience of controlling one's actions and the external events resulting from those actions. This study aimed to critically evaluate the construct validity, robustness, and clinical utility of the Sense of Agency Scale (SoAS) in an Italian-speaking population, using a data-driven approach to explore potential factor structures. A sample of 992 adults completed the SoAS alongside other validated psychological measures, allowing for a comprehensive analysis of the scale's psychometric properties.
View Article and Find Full Text PDFAssociation of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.
Sports Med
January 2025
Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed.
Objective: We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset.
The confavreux lecture: The radiologically isolated syndrome diagnosis, prognosis and perspectives.
Mult Scler
January 2025
UR2CA-URRIS, Université Nice Côte d'Azur, Nice, France.
Radiologically isolated syndrome (RIS) is the earliest documented stage in the disease continuum of multiple sclerosis (MS). It is discovered incidentally in individuals who are asymptomatic but have typical lesions in the brain or spinal cord suggestive of autoimmune inflammatory demyelination. The revised 2023 RIS criteria aim to secure an accurate and timely diagnosis due to the presence of imaging mimics.
View Article and Find Full Text PDFPsychometric evaluation of the chinese version of transgender congruence scale.
BMC Psychol
January 2025
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Background: In China, research on the mental health of transgender populations is increasingly prevalent; however, there is a lack of localized psychological measurement tools that align with the characteristics of this population. The Transgender Congruence Scale (TCS) is widely used internationally. This study aims to assess the reliability, validity, and psychometric characteristics of the Chinese version of the TCS among the Chinese transgender sample.
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