Introduction: The objective of this review is to assess the efficacy and safety of moxibustion for treating patients with functional constipation (FC).

Methods And Analysis: We will electronically search the following databases: OVID MEDLINE, EMBASE, PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, Cochrane library, CINAHL, AMED, China Network Knowledge Infrastructure, Wan-fang Database, China Biomedical Literature Database, and other resources from inception to October 2019, without any language restrictions. Randomised-controlled trials will be included. The primary outcome is the improvement in mean complete spontaneous bowel movements and stool form (utilize the Bristol Stool Form Scale [BSFS]). Secondary outcomes involve the degree of difficulty in defecation, proportion of responders, mean transit time, health-related quality of life, and adverse events rate. The methodological quality will be assessed using the Cochrane risk of bias tool.

Results: This work will summarize clinical evidence to assess the effectiveness and safety of moxibustion treatment for FC patients.

Conclusion: This systematic review and meta-analysis will provide current evidence of the efficacy and safety of moxibustion treating FC.

Systematic Review Registration: PROSPERO, CRD42020157955.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360324PMC
http://dx.doi.org/10.1097/MD.0000000000020910DOI Listing

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