Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.parkreldis.2020.05.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of RGC degeneration in the pathogenesis of glaucoma.
Int J Biol Sci
January 2025
Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, Changchun 130000, Jilin, China.
Glaucoma is a neurodegenerative disorder marked by the loss of retinal ganglion cells (RGCs) and axonal degeneration, resulting in irreversible vision impairment. While intraocular pressure (IOP) is presently acknowledged as the sole modifiable risk factor, the sensitivity of RGCs to IOP varies among individuals. Consequently, progressive vision loss may ensue even when IOP is effectively managed.
View Article and Find Full Text PDFHomonymous hemi-macular atrophy in multiple sclerosis.
Mult Scler
December 2024
Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Background: Retrograde trans-synaptic degeneration (TSD) following retro-chiasmal pathology, typically retro-geniculate in multiple sclerosis (MS), may manifest as homonymous hemi-macular atrophy (HHMA) of the ganglion cell/inner plexiform layer (GCIPL).
Objective: To determine the frequency, association with clinical outcomes, and retinal and radiological features of HHMA in people with MS (PwMS).
Methods: In this cross-sectional study, healthy controls (HC) and PwMS underwent retinal optical coherence tomography scanning.
Amlodipine Attenuates Carrageenan-induced Oxidative Stress Targeting Transsynaptic Neuronal Damage by Promoting Survival of Retinal Ganglion Cells in Adult Zebrafish (.
Ann Neurosci
June 2024
Neurobiology Laboratory, Department of Zoology, School of Life Sciences, Ravenshaw University, Cuttack, Odisha, India.
Background: Transsynaptic degeneration of retinal ganglion cells (RGCs) likely plays a role in progressive loss of vision in glaucoma. Carrageenan (Carr), obtained from seaweed (Rhodophyceae), a sulphated polysaccharide extracted from a species of red algae (), is a reversible gel mostly used in eye-drop preparation due to its hydrocolloid nature. But Carr-induced inflammation causing oxidative stress in animals has not yet been evaluated.
View Article and Find Full Text PDFUnusual co-occurrence of hypertrophic inferior olivary degeneration with infratentorial cavernomatosis and orbital cavernous hemangioma.
Radiol Case Rep
January 2025
Radiology Department, Mohammed Vth military hospital, 10010 Rabat, Morocco.
Article Synopsis
- * Cavernomas and orbital cavernous hemangiomas are specific types of vascular malformations linked to HOD, but their combination is extremely rare, with only one previous case reported.
- * A notable case involved a 26-year-old male with eye bulging and myoclonus, where MRI revealed HOD from cavernous malformations, highlighting the need to consider vascular issues as potential causes of HOD.
Brain alteration of autoimmune thyroid disease: Neuropsychiatric impact, neuroimaging insights, and neurobiological implications.
Front Neuroendocrinol
October 2024
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China; Center for Basic Medical Research and Innovation in Visual System Diseases, Ministry of Education, China. Electronic address:
Article Synopsis
- Autoimmune thyroid disease (AITD) is the most prevalent organ-specific autoimmune disorder, resulting in thyroid dysfunction and autoimmune imbalance, affecting overall quality of life.
- Patients with AITD, even those with normal thyroid function (euthyroid), experience neuropsychiatric issues like anxiety, depression, and cognitive problems, which are linked to changes in brain structure and function.
- The exact cause of these neuropsychiatric symptoms and brain alterations is not fully understood, but it is thought to arise from multiple factors, including thyroid dysfunction, metabolic issues, autoimmune factors, and brain connectivity changes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!