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Causal Relationship Between Autoimmune Rheumatic Diseases and Iridocyclitis: A Bidirectional Two-Sample Mendelian Randomization Study.
Ocul Immunol Inflamm
January 2025
Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany.
Purpose: This study aims to explore the relationship between autoimmune rheumatic diseases (ARDs) and the risk of iridocyclitis (IC) using Mendelian randomization (MR) analysis.
Methods: Data of ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis (JIA), Behcet's disease (BD), and iridocyclitis were obtained from genome-wide association studies with large sample sizes. The instrumental variable utilized in this study for each exposure was the single nucleotide polymorphism.
Incorporation of the central vein sign into the McDonald criteria.
Mult Scler Relat Disord
November 2024
Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, United States. Electronic address:
Background: Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.
Objective: Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.
[Advances in the Pathophysiology and Drug Discovery of Novel Therapeutics for Attention-Deficit/hyperactivity Disorder].
Yakugaku Zasshi
December 2024
Department of Pharmacology, Faculty of Pharmaceutical Science, Health Sciences University of Hokkaido.
Article Synopsis
- ADHD is a neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity, typically treated with psychostimulants like methylphenidate, which have significant side effects and addiction risks.
- * The study used juvenile stroke-prone spontaneously hypertensive rats (SHRSP/Ezo) to explore D-serine levels and NMDA receptor dysfunction in relation to ADHD, finding a lower D-serine/total serine ratio in these rats compared to control rats.
- * Inhibiting DAAO in the mPFC improved the D-serine levels and reduced ADHD-like behaviors in SHRSP/Ezo, suggesting that D-serine metabolism may play a key role in ADHD's pathogenesis and pointing towards potential new treatments
STROKE AS A LIFE-THREATENING COMPLICATION IN CHILDREN WITH LINEAR SCLERODERMA OF FACE.
Georgian Med News
September 2024
Objective: To investigate the spectrum of neurological disorders in children with juvenile localized scleroderma (JLS) on face and JLS without plaques on face and head.
Materials And Methods: 156 children with JLS were examined were with a neurological examination MRI, EEG, genetic thrombophilia markers detection.
Results: Neurological disorders (ND) were found in 56 from 114 (49%) of the patients with scleroderma of head and face (LSH)(group1) and in 30% (13 from 42) with JLS without plaques on face (Group 2).
Paradoxical cerebral embolism three decades after mustard surgery in a patient with complete transposition of the great arteries: a case report.
J Int Med Res
October 2024
Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Atrial switch procedures such as the Mustard operation were previously popular for the complete transposition of the great arteries (i.e. dextro-transposition of the great arteries [d-TGA]).
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