A metal-free asymmetric transfer hydrogenation of unprotected indoles was successfully realized using a catalyst derived from HB(CF) and ()--butylsulfinamide with ammonia borane as a hydrogen source. A variety of indolines were achieved in 40-78% yields with up to 90% ee.
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| http://dx.doi.org/10.1021/acs.orglett.0c01930 | DOI Listing |
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