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Background: Damage to brain white matter often occurs in individuals with chronic kidney disease, which might be related to their cognitive decline. This study aims to investigate tract-specific white matter damage in patients with end-stage kidney disease by using fixel-based analysis.

Methods: Images of 31 end-stage kidney disease patients and 16 normal controls (aged: 61.

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Acquired Ankyloblepharon Correction Using Ocular Surface and Tarsal Mucous Membrane Grafting in Cicatrizing Ocular Surface Diseases.

Ophthalmic Plast Reconstr Surg

January 2025

Hariram Motumal Nasta & Renu Hariram Nasta Ophthalmic Plastic Surgery Services.

Purpose: To report the long-term surgical outcomes of acquired ankyloblepharon correction using mucous membrane graft.

Methods: Five eyes of 4 patients (median age, 19 years) with acquired ankyloblepharon were managed using eyelid splitting and mucous membrane graft anchored to the recti muscles on the bulbar surface in the respective quadrant and onto the bare tarsal surface. Outcome measures include a change in the palpebral fissure width, ability to fit scleral contact lenses, visual acuity, and cosmesis.

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Subcortical Alterations in Newly Diagnosed Epilepsy and Associated Changes in Brain Connectivity and Cognition.

Hum Brain Mapp

November 2024

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Article Synopsis
  • * This study involved a comparison between individuals with newly diagnosed focal epilepsy (NDfE) and healthy controls, using MRI and neuropsychological data to evaluate subcortical shape alterations and their impact on brain connectivity and cognitive function.
  • * Findings indicated significant inward deformation (localized atrophy) in the thalamus and pallidum of NDfE patients, and a correlation between reduced white matter integrity (measured by fractional anisotropy) and this shape deformation, suggesting links to neuropsychological outcomes.
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Purpose: To manage ocular surface complications and recover conjunctival and corneal epithelia after unilateral severe chemical burn.

Methods: We performed simple conjunctival epithelial transplantation (SCET) to obtain renewal of fornix and bulbar-tarsal conjunctiva epithelium, followed by simple limbal epithelial transplantation (SLET) to recover limbal function and epithelial corneal surface. Slit-lamp examination, fluorescein staining, in vivo confocal microscopy, Kheirkhah grading system for symblepharon severity, Wong-Baker FACES Pain Rating Scale, and best-corrected visual acuity were assessed before surgery, at 1 to 3 months after SCET and SLET, and thereafter at 6 to 12 to 36 months.

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White matter correlates of dissociation in a diverse sample of trauma-exposed women.

Psychiatry Res

December 2024

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Ste 6007, Atlanta, GA 30322, USA. Electronic address:

Article Synopsis
  • - This study investigates the relationship between dissociation, a common trauma response, and the microstructure of white matter (WM) in the brain, particularly looking at how brain connectivity may be affected in trauma-exposed women.
  • - Researchers analyzed data from 135 women to examine how different facets of dissociation related to fractional anisotropy (FA), a measure of WM integrity, finding significant negative correlations between FA and overall dissociation across several important brain tracts.
  • - The results suggest that greater severity of dissociation is associated with reduced WM integrity in areas linked to sensory processing, emotional regulation, and memory, highlighting potential targets for therapy and neuromodulation interventions.
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