Sustainable developments of nanotechnology necessitate the exploration of structure-activity relationships (SARs) at nano-bio interfaces. While ferroptosis may contribute in the developments of some severe diseases (e.g., Parkinson's disease, stroke and tumors), the cellular pathways and nano-SARs are rarely explored in diseases elicited by nano-sized ferroptosis inducers. Here we find that WS and MoS nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation. Notably, nano-SAR analysis of 20 transition metal dichalcogenides (TMDs) disclosures the decisive role of surface vacancy in ferroptosis. We therefore develop methanol and sulfide passivation as safe design approaches for TMD nanosheets. These findings are validated in animal lungs by oropharyngeal aspiration of TMD nanosheets. Overall, our study highlights the key cellular events as well as nano-SARs in TMD-induced ferroptosis, which may facilitate the safe design of nanoproducts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359333 | PMC |
| http://dx.doi.org/10.1038/s41467-020-17300-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crystal-Field Effects in the Formation of Wigner-Molecule Supercrystals in Moiré Transition Metal Dichalcogenide Superlattices.
Phys Rev Lett
December 2024
School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332-0430, USA.
For moiré bilayer TMD superlattices, full-configuration-interaction (FCI) calculations are presented that take into account both the intra-moiré-quantum-dot (MQD) charge-carrier Coulombic interactions, as well as the crystal-field effect from the surrounding moiré pockets (inter-moiré-QD interactions). The effective computational embedding strategy introduced here allows for an FCI methodogy that enables the complete interpretation of the counterintuitive experimental observations reported recently in the context of moiré TMD superlattices at integer fillings ν=2 and 4. Two novel states of matter are reported: (i) a genuinely quantum-mechanical supercrystal of sliding Wigner molecules (WMs) for unstrained moiré TMD materials (when the crystal field is commensurate with the trilobal symmetry of the confining potential in each embedded MQD) and (ii) a supercrystal of pinned Wigner molecules when the crystal field is incommensurate with the trilobal symmetry or straining of the whole material is involved.
View Article and Find Full Text PDFEffect of Halogenation on the Optical, Electrical, and Thermal Properties of the Model Compound [Me(i-Pr)N][SnBr].
Inorg Chem
January 2025
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, P. R. China.
Organic-inorganic hybrid lead halides have been extensively studied due to their outstanding physical properties and diverse compositional elements. However, environmentally benign tin-based hybrids with remarkable flexibility in bandgap engineering have been less investigated. Herein, we report the successful design and synthesis of three tin-based organic-inorganic hybrid compounds through precise molecular modification: [Me(i-Pr)N][SnBr] (), [MeCHCl(i-Pr)N][SnBr] (), and [MeCHBr(i-Pr-Br)N][SnBr] ().
View Article and Find Full Text PDFEvaluation of marginal accuracy of polyetheretherketone and zirconia copings fabricated using computer-aided design/computer-aided manufacturing technique: An in vitro study.
J Indian Prosthodont Soc
January 2025
Department of Prosthodontics, Chhattisgarh Dental College and Hospital, Rajnandgaon, Chhattishgarh, India.
Aim: The aim of this study was to compare the marginal accuracy of polyetheretherketone (PEEK) and zirconia copings fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM) technology, and to assess the impact of their material properties on accuracy when produced with a 4-axis milling system under controlled conditions.
Settings And Design: The study employed an in vitro design with a stainless steel die model featuring a 6 mm axial wall height, a 6-degree total occlusal convergence, and a radial shoulder finish line.
Materials And Methods: Thirty stone dies were created from silicone impressions of the metal die and poured using type-IV dental stone.
Incorporation of opacifier to Type III alpha gypsum and its effect on scannability and linear setting expansion - An in vitro study.
J Indian Prosthodont Soc
January 2025
Department of Prosthodontics and Crown and Bridge, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.
Aim: This study aims to enhance the scannability of Type III alpha gypsum by incorporating an opacifier and to evaluate its effect on the LSE property.
Setting And Design: In vitro - Comparative study.
Materials And Methods: The base powder of Type III alpha gypsum was divided into three groups: Group I (100 g of base powder), Group II (90 g of base powder with 10 g of TiO2), and Group III (80 g of base powder with 20 g of TiO2).
Electride transition in liquid aluminum under high pressure and high temperature.
J Chem Phys
January 2025
Key Laboratory of Efficient Low-carbon Energy Conversion and Utilization of Jiangsu Provincial Higher Education Institutions, School of Physical Science and Technology, Suzhou University of Science and Technology, Suzhou 215009, China.
Despite the conventional view of liquid aluminum (l-Al) as a simple metal governed by the free-electron model, it exhibits unique bonding characteristics. This study uncovers a gradual transition from free electron to electride behavior in l-Al at high pressure and temperature, forming a type of two-component liquid where atomic and electride states coexist. The proportion of electride increases with pressure and temperature until reaching saturation, leading to notable changes in the pair-correlation function and coordination number of l-Al at saturation pressure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!