AI Article Synopsis
- Prostate cancer screening involves complex tests and risk assessments using blood, urine, and tissue biomarkers alongside imaging methods.
- A new noninvasive screening tool focuses on analyzing specific HOXB13 mutations in urine samples to better determine who should undergo prostate biopsies.
- This innovative method aims to identify cancer presence effectively, reduce unnecessary biopsies, and is considered reliable and cost-effective for future prostate cancer screening.
Article Abstract
Prostate cancer screening is a challenging and vital issue in the aspects of the current tests and risk assessments. Prostate cancer risk assessments are currently carried out by using blood, urine and tissue biomarkers with radiological imaging methods. Here, we introduce a novel noninvasive screening tool for a further in-depth selection of eligible cases for prostate biopsies which is based on sequencing somatic and hereditary HOXB13 mutations in urine samples. This approach provides diagnostic information to the physician about the presence of prostate cancer while aiming to screen for specific prostate biopsies and save biopsies potentially when there are no mutations related to prostate cancer. Findings suggest that this method is reliable, cost-effective, and has a promising potential in prostate cancer screening.
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| http://dx.doi.org/10.1016/j.currproblcancer.2020.100616 | DOI Listing |
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